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5-Fluorouracil (5-FU)

别名: Fluorouracil, NSC 19893

目录号：S1209

Purity: 99.98%

5-FU (5-Fluorouracil)是DNA/RNA合成抑制剂，在肿瘤细胞中通过抑制胸苷酸合成酶（TS）而干扰核苷酸合成。Fluorouracil 可诱导细胞凋亡并可用于治疗HIV。

5-Fluorouracil (5-FU) Chemical Structure

CAS: 51-21-8

规格

价格

库存

购买数量

10mM (1mL in DMSO)

711

现货

100mg

441

现货

200mg

711

现货

2211.3

现货

10g

8910

现货

更大包装

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产品质控

批次：

S120901

S120904

S120905

S120906

纯度：

99.98%

Nature medicine文章证明Selleck质量第一

COA

NMR

HPLC

Microanalysis

为什么要做元素分析？

SDS

说明书

Nature medicine文章证明Selleck质量第一

COA

HPLC

Microanalysis

为什么要做元素分析？

SDS

说明书

Nature medicine文章证明Selleck质量第一

COA

HPLC

Microanalysis

为什么要做元素分析？

SDS

说明书

Nature medicine文章证明Selleck质量第一

COA

HPLC

Microanalysis

为什么要做元素分析？

SDS

说明书

99.98

常与5-Fluorouracil (5-FU)一起在实验中被使用的化合物

Oxaliplatin

5-Fluorouracil和Oxaliplatin联合肝动脉插管化疗是治疗晚期胆囊癌的一种可接受且耐受性良好的治疗方法。

Irinotecan

5-Fluorouracil和Irinotecan加亚叶酸纳米脂质体对于转移性胰腺癌患者有效且可耐受。

Cisplatin

在实验性牙周炎的大鼠中，5-Fluorouracil和Cisplatin显示出 RANKL、TNF-α 和 IL-1β 的高免疫标记模式。

Paclitaxel

对于LoVo结肠癌细胞系，Paclitaxel表现出比5-FU更高的放射增敏作用，并且有潜力作为结肠癌5-FU的替代放射增敏剂。

Doxorubicin (Adriamycin) Hydrochloride

5-Fluorouracil和Doxorubicin显著抑制MDA-MB-231异种移植肿瘤小鼠模型中肿瘤生长的进展。

5-Fluorouracil (5-FU)相关产品

相关信号通路图

DNA/RNA Synthesis信号通路图

细胞实验数据示例

细胞系

实验类型

给药浓度

孵育时间

活性描述

文献信息(PMID)

colon cancer

Cytotoxicity assay

10 uM

48 hrs

Cytotoxicity against human colon cancer cells at 10 uM after 48 hrs, GI50 = 8.4 μM.

24469112

leukemia

Cytotoxicity assay

10 uM

48 hrs

Cytotoxicity against human leukemia cells at 10 uM after 48 hrs, GI50 = 15.1 μM.

24469112

prostate cancer

Cytotoxicity assay

10 uM

48 hrs

Cytotoxicity against human prostate cancer cells at 10 uM after 48 hrs, GI50 = 22.7 μM.

24469112

renal cancer

Cytotoxicity assay

10 uM

48 hrs

Cytotoxicity against human renal cancer cells at 10 uM after 48 hrs, GI50 = 45.6 μM.

24469112

HL-60

Growth Inhibition Assay

72 h

IC50=8.601 μg/mL

24095176

NCI-H292

Growth Inhibition Assay

72 h

IC50> 25 μg/mL

24095176

HT-29

Growth Inhibition Assay

72 h

IC50> 25 μg/mL

24095176

MCF-7

Growth Inhibition Assay

72 h

IC50=20 μg/mL

24095176

P388

Antiproliferative assay

48 hrs

Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay, IC50 = 0.609 μM.

2778449

HT-29

Antiproliferative assay

96 hrs

Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay, IC50 = 0.69 μM.

2778449

L1210

Growth inhibition assay

48 hrs

In vitro growth inhibition of L1210 cells 48 hours after administration of compound, IC50 = 0.12 μM.

7629806

L1210

Growth inhibition assay

24 hrs

In vitro growth inhibition of L1210 cells 24 hours after administration of compound, IC50 = 0.22 μM.

7629806

L1210

Growth inhibition assay

8 hrs

In vitro growth inhibition of L1210 cells 8 hours after administration of compound, IC50 = 0.63 μM.

7629806

L1210

Growth inhibition assay

2 hrs

In vitro growth inhibition of L1210 cells 2 hours after administration of compound, IC50 = 2.2 μM.

7629806

L1210

Growth inhibition assay

48 hrs

Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 48 hr, IC50 = 0.125 μM.

11063625

L1210

Growth inhibition assay

24 hrs

Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 24 hr, IC50 = 0.22 μM.

11063625

L1210

Growth inhibition assay

8 hrs

Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 8 hr, IC50 = 0.63 μM.

11063625

L1210

Growth inhibition assay

2 hrs

Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 2 hr, IC50 = 2.2 μM.

11063625

Colon 26-L5

Antiproliferative assay

72 hrs

Antiproliferative activity against mouse Colon 26-L5 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 0.5 μM.

11575942

B16-BL6

Antiproliferative assay

72 hrs

Antiproliferative activity against mouse B16-BL6 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 0.6 μM.

11575942

HT1080

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT1080 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.5 μM.

11575942

L1210

Growth inhibition assay

48 hrs

Growth inhibition in L1210 mouse leukemia cells after 48 hr treatment, IC50 = 0.2 μM.

11728193

L1210

Growth inhibition assay

24 hrs

Growth inhibition in L1210 mouse leukemia cells after 24 h treatment, IC50 = 0.36 μM.

11728193

L1210

Growth inhibition assay

8 hrs

Growth inhibition in L1210 mouse leukemia cells after 8 h treatment, IC50 = 1.01 μM.

11728193

L1210

Growth inhibition assay

2 hrs

Growth inhibition in L1210 mouse leukemia cells after 2 hr treatment, IC50 = 2.5 μM.

11728193

HT1080

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay, IC50 = 3.7 μM.

14640513

HCT116

Cytotoxicity assay

96 hrs

Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay, IC50 = 4.93 μM.

15387639

DLD1

Cytotoxicity assay

96 hrs

Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay, IC50 = 7.38 μM.

15387639

HeLaS3

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLaS3 cells after 72 hrs by WST1 assay, IC50 = 5.4 μM.

15387656

A549

Cytotoxicity assay

96 hrs

Cytotoxicity against human A549 cells after 96 hrs by MTT assay, IC50 = 1.4 μM.

16499317

HCT8

Cytotoxicity assay

96 hrs

Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay, IC50 = 4.2 μM.

16499317

BEL-7402

Cytotoxicity assay

96 hrs

Cytotoxicity against human BEL-7402 cells after 96 hrs by MTT assay, IC50 = 4.2 μM.

16499317

A2780

Cytotoxicity assay

96 hrs

Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50 = 5 μM.

16499317

BGC823

Cytotoxicity assay

96 hrs

Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay, IC50 = 5.4 μM.

16499317

Cytotoxicity assay

48 hrs

Cytotoxicity against human KB cells after 48 hrs, IC50 = 13.4 μM.

17000031

HL60

Cytotoxicity assay

48 hrs

Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.16 μM.

17291040

Bel7402

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay, IC50 = 23.21 μM.

17291040

BGC823

Cytotoxicity assay

48 hrs

Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay, IC50 = 31.16 μM.

17291040

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs, IC50 = 4.8 μM.

17336074

MDA-MB-231

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDA-MB-231 cells after 72 hrs, IC50 = 9.6 μM.

17336074

Caco-2

Growth inhibition assay

10 days

Growth inhibition of human Caco-2 cells after 10 days, IC50 = 1.5 μM.

17337193

L1210/0

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse L1210/0 cells after 48 hrs, IC50 = 0.31 μM.

17341060

SW480

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW480 cells after 72 hrs by MTT method, IC50 = 8.1 μM.

17524655

MDA-MB-435S

Antiproliferative assay

72 hrs

Antiproliferative activity against human MDA-MB-435S cells after 72 hrs by MTT method, IC50 = 14.5 μM.

17524655

HCCLM7

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCCLM7 cells after 72 hrs by MTT method, IC50 = 18.6 μM.

17524655

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs, IC50 = 0.3 μM.

17548198

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs, IC50 = 2.8 μM.

17548198

SW480

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW480 cells after 72 hrs, IC50 = 3.5 μM.

17548198

SW48

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW48 cells after 72 hrs, IC50 = 5.3 μM.

17548198

Caco-2

Growth inhibition assay

10 days

Growth inhibition of human Caco-2 cells after 10 days, IC50 = 1.5 μM.

17555969

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against A549 cells after 48 hrs by MTT assay, IC50 = 9.2 μM.

17604394

Caco-2

Growth inhibition assay

10 days

Growth inhibition of human Caco-2 cells after 10 days, IC50 = 1.5 μM.

18037195

MCF7

Antiproliferative assay

3 days

Antiproliferative activity against human MCF7 cells after 3 days by SRB assay, IC50 = 4.32 μM.

18069093

L1210

Antiproliferative assay

2 days

Antiproliferative activity against mouse L1210 cells after 2 days by MTT assay, IC50 = 0.69 μM.

18424155

MCF7

Antiproliferative assay

3 days

Antiproliferative activity against human MCF7 cells after 3 days by MTT assay, IC50 = 4.5 μM.

18424155

MiaPaCa2

Antiproliferative assay

3 days

Antiproliferative activity against human MiaPaCa2 cells after 3 days by MTT assay, IC50 = 6.5 μM.

18424155

SW620

Antiproliferative assay

3 days

Antiproliferative activity against human SW620 cells after 3 days by MTT assay, IC50 = 8.7 μM.

18424155

HepG2

Antiproliferative assay

3 days

Antiproliferative activity against human HepG2 cells after 3 days by MTT assay, IC50 = 9.2 μM.

18424155

CEM

Antiproliferative assay

3 days

Antiproliferative activity against human CEM cells after 3 days by MTT assay, IC50 = 9.23 μM.

18424155

WI38

Cytotoxicity assay

3 days

Cytotoxicity against human WI38 cells after 3 days by MTT assay, IC50 = 10 μM.

18424155

HeLa

Antiproliferative assay

3 days

Antiproliferative activity against human HeLa cells after 3 days by MTT assay, IC50 = 16 μM.

18424155

Molt4/C8

Antiproliferative assay

3 days

Antiproliferative activity against human Molt4/C8 cells after 3 days by MTT assay, IC50 = 20 μM.

18424155

colon 26-L5

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50 = 0.46 μM.

18440233

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 0.77 μM.

18440233

LLC

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay, IC50 = 2.59 μM.

18440233

B16-BL6

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay, IC50 = 5.78 μM.

18440233

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 9.19 μM.

18440233

HT1080

Cytotoxicity assay

72 hrs

Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay, IC50 = 9.45 μM.

18440233

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells expressing p53 gene after 72 hrs by proliferative assay, IC50 = 6.36 μM.

18469809

A2780

Antiproliferative assay

72 hrs

Antiproliferative activity against human A2780 cells expressing p53 gene after 72 hrs by proliferative assay, IC50 = 7.21 μM.

18469809

COLO205

Antiproliferative assay

72 hrs

Antiproliferative activity against p53 deficient human COLO205 cells after 72 hrs, IC50 = 11.63 μM.

18469809

U2OS

Antiproliferative assay

72 hrs

Antiproliferative activity against human U2OS cells expressing p53 gene after 72 hrs by proliferative assay, IC50 = 13.18 μM.

18469809

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells expressing p53 gene after 72 hrs by proliferative assay, IC50 = 13.77 μM.

18469809

HCT15

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT15 cells expressing p53 gene after 72 hrs by proliferative assay, IC50 = 18.24 μM.

18469809

SW480

Antiproliferative assay

72 hrs

Antiproliferative activity against p53 deficient human SW480 cells after 72 hrs by proliferative assay, IC50 = 26.26 μM.

18469809

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells expressing p53 gene after 72 hrs by proliferative assay, IC50 = 26.67 μM.

18469809

HCT116/E6

Antiproliferative assay

72 hrs

Antiproliferative activity against p53 deficient human HCT116/E6 cells after 72 hrs by proliferative assay, IC50 = 28.91 μM.

18469809

A2780/E6

Antiproliferative assay

72 hrs

Antiproliferative activity against p53 deficient human A2780/E6 cells after 72 hrs by proliferative assay, IC50 = 38.67 μM.

18469809

HL60

Antiproliferative assay

3 days

Antiproliferative activity against human HL60 cells after 3 days by trypan blue staining, GI50 = 3.8 μM.

18491866

HaCaT

Growth inhibition assay

72 hrs

Growth inhibition of human HaCaT cells after 72 hrs by MTT assay, IC50 = 0.4 μM.

18640746

H460

Growth inhibition assay

72 hrs

Growth inhibition of human H460 cells after 72 hrs by MTT assay, IC50 = 2 μM.

18640746

HeLa

Growth inhibition assay

72 hrs

Growth inhibition of human HeLa cells after 72 hrs by MTT assay, IC50 = 4 μM.

18640746

SW620

Growth inhibition assay

72 hrs

Growth inhibition of human SW620 cells after 72 hrs by MTT assay, IC50 = 9 μM.

18640746

MIAPaCa2

Growth inhibition assay

72 hrs

Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTT assay, IC50 = 10 μM.

18640746

MCF7

Growth inhibition assay

72 hrs

Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, IC50 = 15 μM.

18640746

3T3

Cytotoxicity assay

48 hrs

Cytotoxicity against BALB mouse 3T3 cells after 48 hrs, GI50 = 1.54 μM.

18798609

H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human H460 cells after 48 hrs, GI50 = 4.1 μM.

18798609

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs, GI50 = 6.5 μM.

18798609

HT29

Cytotoxicity assay

48 hrs

Cytotoxicity against human HT29 cells after 48 hrs, GI50 = 8.9 μM.

18798609

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells after 48 hrs, GI50 = 14.6 μM.

18798609

DU145

Cytotoxicity assay

48 hrs

Cytotoxicity against human DU145 cells after 48 hrs, GI50 = 15.4 μM.

18798609

K562

Cytotoxicity assay

48 hrs

Cytotoxicity against human K562 cells after 48 hrs, GI50 = 16.7 μM.

18798609

M14

Cytotoxicity assay

48 hrs

Cytotoxicity against human M14 cells after 48 hrs, GI50 = 22.4 μM.

18798609

colon cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human Colon cancer cells after 48 hrs, GI50 = 8.37 μM.

18950904

leukemia cell

Growth inhibition assay

48 hrs

Growth inhibition of human leukemia cells after 48 hrs, GI50 = 15.09 μM.

18950904

prostate cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human prostate cancer cells after 48 hrs, GI50 = 22.7 μM.

18950904

renal cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human renal cancer cells after 48 hrs, GI50 = 45.6 μM.

18950904

PC3

Antiproliferative assay

48 hrs

Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, IC50 = 0.016 μM.

19423198

A431

Antiproliferative assay

48 hrs

Antiproliferative activity against human A431 cells after 48 hrs by MTT assay, IC50 = 0.018 μM.

19423198

MCF7

Antiproliferative assay

24 hrs

Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay, IC50 = 4.3 μM.

19560842

Bel7402

Antiproliferative assay

24 hrs

Antiproliferative activity against human Bel7402 cells after 24 hrs by MTT assay, IC50 = 4.7 μM.

19560842

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, GI50 = 10 μM.

19572613

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, GI50 = 15 μM.

19572613

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 10 μM.

19618920

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 15 μM.

19618920

SW1573

Growth inhibition assay

48 hrs

Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay, GI50 = 4.1 μM.

19664930

A2780

Growth inhibition assay

48 hrs

Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 4.4 μM.

19664930

HBL100

Growth inhibition assay

48 hrs

Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay, GI50 = 5.5 μM.

19664930

HeLa

Growth inhibition assay

48 hrs

Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay, GI50 = 19 μM.

19664930

T47D

Growth inhibition assay

48 hrs

Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay, GI50 = 29 μM.

19664930

Colon 26-L5

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay, IC50 = 0.41 μM.

19689125

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 0.44 μM.

19689125

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 5.91 μM.

19689125

B16-BL6

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay, IC50 = 7.39 μM.

19689125

HT1080

Cytotoxicity assay

72 hrs

Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay, IC50 = 8.58 μM.

19689125

OVCAR-3

Anticancer assay

48 hrs

Anticancer activity against human OVCAR-3 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.01585 μM.

19740574

Anticancer assay

48 hrs

Anticancer activity against human SR cells after 48 hrs by sulforhodamine B assay, GI50 = 0.02399 μM.

19740574

RPMI8266

Anticancer assay

48 hrs

Anticancer activity against human RPMI8266 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.04467 μM.

19740574

MALME-3M

Anticancer assay

48 hrs

Anticancer activity against human MALME-3M cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05129 μM.

19740574

HCC2998

Anticancer assay

48 hrs

Anticancer activity against human HCC2998 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05248 μM.

19740574

NCI-H460

Anticancer assay

48 hrs

Anticancer activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05623 μM.

19740574

SF539

Anticancer assay

48 hrs

Anticancer activity against human SF539 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.0631 μM.

19740574

Caki1

Anticancer assay

48 hrs

Anticancer activity against human Caki1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07244 μM.

19740574

MDA-MB-435

Anticancer assay

48 hrs

Anticancer activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07244 μM.

19740574

MCF7

Anticancer assay

48 hrs

Anticancer activity against human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07943 μM.

19740574

HCT15

Anticancer assay

48 hrs

Anticancer activity against human HCT15 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.10965 μM.

19740574

COLO205

Anticancer assay

48 hrs

Anticancer activity against human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.15849 μM.

19740574

NCI-H322M

Anticancer assay

48 hrs

Anticancer activity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay, GI50 = 0.17783 μM.

19740574

HT-29

Anticancer assay

48 hrs

Anticancer activity against human HT-29 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.17783 μM.

19740574

A549

Anticancer assay

48 hrs

Anticancer activity against human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.19055 μM.

19740574

KM12

Anticancer assay

48 hrs

Anticancer activity against human KM12 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2138 μM.

19740574

HCT116

Anticancer assay

48 hrs

Anticancer activity against human HCT116 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.22909 μM.

19740574

SF295

Anticancer assay

48 hrs

Anticancer activity against human SF295 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.22909 μM.

19740574

LOXIMVI

Anticancer assay

48 hrs

Anticancer activity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay, GI50 = 0.24547 μM.

19740574

ACHN

Anticancer assay

48 hrs

Anticancer activity against human ACHN cells after 48 hrs by sulforhodamine B assay, GI50 = 0.29512 μM.

19740574

NCI/ADR-RES

Anticancer assay

48 hrs

Anticancer activity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay, GI50 = 0.31623 μM.

19740574

NCI-H23

Anticancer assay

48 hrs

Anticancer activity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.33113 μM.

19740574

MOLT4

Anticancer assay

48 hrs

Anticancer activity against human MOLT4 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.35481 μM.

19740574

DU145

Anticancer assay

48 hrs

Anticancer activity against human DU145 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.36308 μM.

19740574

HOP62

Anticancer assay

48 hrs

Anticancer activity against human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.39811 μM.

19740574

A498

Anticancer assay

48 hrs

Anticancer activity against human A498 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.39811 μM.

19740574

SK-MEL-5

Anticancer assay

48 hrs

Anticancer activity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.46774 μM.

19740574

SN12C

Anticancer assay

48 hrs

Anticancer activity against human SN12C cells after 48 hrs by sulforhodamine B assay, GI50 = 0.50119 μM.

19740574

UACC62

Anticancer assay

48 hrs

Anticancer activity against human UACC62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.52481 μM.

19740574

786-0

Anticancer assay

48 hrs

Anticancer activity against human 786-0 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.72444 μM.

19740574

U251

Anticancer assay

48 hrs

Anticancer activity against human U251 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.91201 μM.

19740574

SW620

Anticancer assay

48 hrs

Anticancer activity against human SW620 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.93325 μM.

19740574

M14

Anticancer assay

48 hrs

Anticancer activity against human M14 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.97724 μM.

19740574

SK-MEL-28

Anticancer assay

48 hrs

Anticancer activity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.02329 μM.

19740574

TK10

Anticancer assay

48 hrs

Anticancer activity against human TK10 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.12202 μM.

19740574

IGROV1

Anticancer assay

48 hrs

Anticancer activity against human IGROV1 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.23027 μM.

19740574

UO31

Anticancer assay

48 hrs

Anticancer activity against human UO31 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.41254 μM.

19740574

SF268

Anticancer assay

48 hrs

Anticancer activity against human SF268 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.58489 μM.

19740574

OVCAR8

Anticancer assay

48 hrs

Anticancer activity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.7378 μM.

19740574

HL-60(TB)

Anticancer assay

48 hrs

Anticancer activity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay, GI50 = 2.29087 μM.

19740574

PC3

Anticancer assay

48 hrs

Anticancer activity against human PC3 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.34423 μM.

19740574

RXF393

Anticancer assay

48 hrs

Anticancer activity against human RXF393 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.63027 μM.

19740574

K562

Anticancer assay

48 hrs

Anticancer activity against human K562 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.54813 μM.

19740574

UACC257

Anticancer assay

48 hrs

Anticancer activity against human UACC257 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.54813 μM.

19740574

SNB19

Anticancer assay

48 hrs

Anticancer activity against human SNB19 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.80189 μM.

19740574

OVCAR4

Anticancer assay

48 hrs

Anticancer activity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay, GI50 = 4.46684 μM.

19740574

MDA-MB-231

Anticancer assay

48 hrs

Anticancer activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay, GI50 = 6.60693 μM.

19740574

NCI-H522

Anticancer assay

48 hrs

Anticancer activity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay, GI50 = 7.24436 μM.

19740574

T47D

Anticancer assay

48 hrs

Anticancer activity against human T47D cells after 48 hrs by sulforhodamine B assay, GI50 = 8.12831 μM.

19740574

CCRF-CEM

Anticancer assay

48 hrs

Anticancer activity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay, GI50 = 9.77237 μM.

19740574

Hs 578T

Anticancer assay

48 hrs

Anticancer activity against human Hs 578T cells after 48 hrs by sulforhodamine B assay, GI50 = 9.77237 μM.

19740574

BT549

Anticancer assay

48 hrs

Anticancer activity against human BT549 cells after 48 hrs by sulforhodamine B assay, GI50 = 10.7152 μM.

19740574

OVCAR5

Anticancer assay

48 hrs

Anticancer activity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay, GI50 = 10.9648 μM.

19740574

SKOV3

Anticancer assay

48 hrs

Anticancer activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay, GI50 = 21.8776 μM.

19740574

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 0.3 μM.

19743863

T47D

Antiproliferative assay

72 hrs

Antiproliferative activity against human T47D cells after 72 hrs by MTT assay, IC50 = 0.6 μM.

19743863

MES-SA

Antiproliferative assay

72 hrs

Antiproliferative activity against human MES-SA cells after 72 hrs by MTT assay, IC50 = 1.1 μM.

19743863

SW480

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay, IC50 = 2.1 μM.

19743863

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 2.6 μM.

19743863

UACC-812

Antiproliferative assay

72 hrs

Antiproliferative activity against human UACC-812 cells after 72 hrs by MTT assay, IC50 = 3.1 μM.

19743863

Antiproliferative assay

72 hrs

Antiproliferative activity against human RL cells after 72 hrs by MTT assay, IC50 = 3.2 μM.

19743863

SW48

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW48 cells after 72 hrs by MTT assay, IC50 = 4.4 μM.

19743863

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 10 μM.

19795843

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 15 μM.

19795843

Cytotoxicity assay

72 hrs

Cytotoxicity against human KB cells after 72 hrs MTT assay, IC50 = 12.5 μM.

19846302

HT1080

Cytotoxicity assay

72 hrs

Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay, IC50 = 5.2 μM.

19919052

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 10 μM.

19919065

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 15 μM.

19919065

COLO205

Growth inhibition assay

48 hrs

Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, IC50 = 21 μM.

19939522

HCT116

Cytotoxicity assay

24 hrs

Cytotoxicity against human HCT116 cells after 24 hrs by trypan blue exclusion assay, IC50 = 3.03 μM.

20163895

MOLT4

Antitumor assay

24 hrs

Antitumor activity against human MOLT4 cells after 24 hrs by MTT assay, IC50 = 0.03 μM.

20211564

H460

Antitumor assay

24 hrs

Antitumor activity against human H460 cells after 24 hrs by MTT assay, IC50 = 2 μM.

20211564

HCT116

Antitumor assay

24 hrs

Antitumor activity against human HCT116 cells after 24 hrs by MTT assay, IC50 = 4 μM.

20211564

SW620

Antitumor assay

24 hrs

Antitumor activity against human SW620 cells after 24 hrs by MTT assay, IC50 = 9 μM.

20211564

MCF7

Antitumor assay

24 hrs

Antitumor activity against human MCF7 cells after 24 hrs by MTT assay, IC50 = 15 μM.

20211564

colon cancer

Antitumor assay

48 hrs

Antitumor activity against human colon cancer cells after 48 hrs by SRB assay, GI50 = 8.4 μM.

20350811

leukemia

Antitumor assay

48 hrs

Antitumor activity against human leukemia cells after 48 hrs by SRB assay, GI50 = 15.1 μM.

20350811

prostate cancer

Antitumor assay

48 hrs

Antitumor activity against human prostate cancer cells after 48 hrs by SRB assay, GI50 = 22.7 μM.

20350811

renal cancer

Antitumor assay

48 hrs

Antitumor activity against human renal cancer cells after 48 hrs by SRB assay, GI50 = 45.6 μM.

20350811

Cytotoxicity assay

3 days

Cytotoxicity against human KB cells after 3 days by MTT assay, IC50 = 4.46 μM.

20356655

SFME

Antiproliferative assay

24 hrs

Antiproliferative activity against mouse SFME cells after 24 hrs by MTT assay, IC50 = 3.2 μM.

20398972

r/m HM-SFME-1

Antiproliferative assay

24 hrs

Antiproliferative activity against mouse r/m HM-SFME-1 cells after 24 hrs by MTT assay, IC50 = 48.5 μM.

20398972

H460

Antiproliferative assay

24 hrs

Antiproliferative activity against human H460 cells after 24 hrs by trypan blue exclusion assay, IC50 = 2.7 μM.

20403701

MDA231

Antiproliferative assay

24 hrs

Antiproliferative activity against human MDA231 cells after 24 hrs by trypan blue exclusion assay, IC50 = 3.5 μM.

20403701

A549

Antiproliferative assay

24 hrs

Antiproliferative activity against human A549 cells after 24 hrs by trypan blue exclusion assay, IC50 = 5.4 μM.

20403701

MCF7

Antiproliferative assay

24 hrs

Antiproliferative activity against human MCF7 cells after 24 hrs by trypan blue exclusion assay, IC50 = 15.2 μM.

20403701

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 10 μM.

20405881

SKBR3

Antiproliferative assay

48 hrs

Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay, GI50 = 3 μM.

20438092

MCF7/BUS

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7/BUS cells expressing estrogen receptor after 48 hrs by SRB assay, GI50 = 6.2 μM.

20438092

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay, GI50 = 8.3 μM.

20438092

T47D

Antiproliferative assay

48 hrs

Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay, GI50 = 47 μM.

20438092

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 1.93 μM.

20494492

DU145

Cytotoxicity assay

72 hrs

Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50 = 2.19 μM.

20494492

SGC7901

Cytotoxicity assay

72 hrs

Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 2.95 μM.

20494492

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 9.7 μM.

20494492

K562

Cytotoxicity assay

72 hrs

Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50 = 45.4 μM.

20494492

OVCAR-3

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR-3 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.01585 μM.

20850204

Growth inhibition assay

48 hrs

Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay, GI50 = 0.02399 μM.

20850204

RPMI8266

Growth inhibition assay

48 hrs

Growth inhibition of human RPMI8266 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.04467 μM.

20850204

MALME-3M

Growth inhibition assay

48 hrs

Growth inhibition of human MALME-3M cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05129 μM.

20850204

HCC2998

Growth inhibition assay

48 hrs

Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05248 μM.

20850204

NCI-H460

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05623 μM.

20850204

SF539

Growth inhibition assay

48 hrs

Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.0631 μM.

20850204

Caki1

Growth inhibition assay

48 hrs

Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07244 μM.

20850204

MDA-MB-435

Growth inhibition assay

48 hrs

Growth inhibition of human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07244 μM.

20850204

MCF7

Growth inhibition assay

48 hrs

Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07943 μM.

20850204

HCT15

Growth inhibition assay

48 hrs

Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.10965 μM.

20850204

COLO205

Growth inhibition assay

48 hrs

Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.15849 μM.

20850204

HT-29

Growth inhibition assay

48 hrs

Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.17783 μM.

20850204

NCI-H322M

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H322M cells after 48 hrs by sulforhodamine B assay, GI50 = 0.17783 μM.

20850204

A549

Growth inhibition assay

48 hrs

Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.19055 μM.

20850204

KM12

Growth inhibition assay

48 hrs

Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2138 μM.

20850204

HCT116

Growth inhibition assay

48 hrs

Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.22909 μM.

20850204

SF295

Growth inhibition assay

48 hrs

Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.22909 μM.

20850204

LOXIMVI

Growth inhibition assay

48 hrs

Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay, GI50 = 0.24547 μM.

20850204

ACHN

Growth inhibition assay

48 hrs

Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay, GI50 = 0.29512 μM.

20850204

NCI/ADR-RES

Growth inhibition assay

48 hrs

Growth inhibition of human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay, GI50 = 0.31623 μM.

20850204

NCI-H23

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.33113 μM.

20850204

MOLT4

Growth inhibition assay

48 hrs

Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.35481 μM.

20850204

DU145

Growth inhibition assay

48 hrs

Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.36308 μM.

20850204

HOP62

Growth inhibition assay

48 hrs

Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.39811 μM.

20850204

A498

Growth inhibition assay

48 hrs

Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.39811 μM.

20850204

SK-MEL-5

Growth inhibition assay

48 hrs

Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.46774 μM.

20850204

SN12C

Growth inhibition assay

48 hrs

Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay, GI50 = 0.50119 μM.

20850204

UACC62

Growth inhibition assay

48 hrs

Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.52481 μM.

20850204

786-0

Growth inhibition assay

48 hrs

Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.72444 μM.

20850204

U251

Growth inhibition assay

48 hrs

Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.91201 μM.

20850204

SW620

Growth inhibition assay

48 hrs

Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.93325 μM.

20850204

M14

Growth inhibition assay

48 hrs

Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.97724 μM.

20850204

SK-MEL-28

Growth inhibition assay

48 hrs

Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.02329 μM.

20850204

TK10

Growth inhibition assay

48 hrs

Growth inhibition of human TK10 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.12202 μM.

20850204

IGROV1

Growth inhibition assay

48 hrs

Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.23027 μM.

20850204

UO31

Growth inhibition assay

48 hrs

Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.41254 μM.

20850204

SF268

Growth inhibition assay

48 hrs

Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.58489 μM.

20850204

OVCAR8

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.7378 μM.

20850204

HL-60(TB)

Growth inhibition assay

48 hrs

Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay, GI50 = 2.29087 μM.

20850204

PC3

Growth inhibition assay

48 hrs

Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.34423 μM.

20850204

RXF393

Growth inhibition assay

48 hrs

Growth inhibition of human RXF393 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.63027 μM.

20850204

K562

Growth inhibition assay

48 hrs

Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.54813 μM.

20850204

UACC257

Growth inhibition assay

48 hrs

Growth inhibition of human UACC257 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.54813 μM.

20850204

SNB19

Growth inhibition assay

48 hrs

Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.80189 μM.

20850204

OVCAR4

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay, GI50 = 4.46684 μM.

20850204

MDA-MB-231

Growth inhibition assay

48 hrs

Growth inhibition of human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay, GI50 = 6.60693 μM.

20850204

NCI-H522

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay, GI50 = 7.24436 μM.

20850204

T47D

Growth inhibition assay

48 hrs

Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay, GI50 = 8.12831 μM.

20850204

CCRF-CEM

Growth inhibition assay

48 hrs

Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay, GI50 = 9.77237 μM.

20850204

Hs 578T

Growth inhibition assay

48 hrs

Growth inhibition of human Hs 578T cells after 48 hrs by sulforhodamine B assay, GI50 = 9.77237 μM.

20850204

BT549

Growth inhibition assay

48 hrs

Growth inhibition of human BT549 cells after 48 hrs by sulforhodamine B assay, GI50 = 10.7152 μM.

20850204

OVCAR5

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay, GI50 = 10.9648 μM.

20850204

SKOV3

Growth inhibition assay

48 hrs

Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay, GI50 = 21.8776 μM.

20850204

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells expressing p53 after 72 hrs by celltiter-glo assay, IC50 = 12 μM.

20873740

A2780

Antiproliferative assay

72 hrs

Antiproliferative activity against human A2780 cells expressing p53 after 72 hrs by celltiter-glo assay, IC50 = 14 μM.

20873740

U2OS

Antiproliferative assay

72 hrs

Antiproliferative activity against human U2OS cells expressing p53 after 72 hrs by celltiter-glo assay, IC50 = 16 μM.

20873740

p53 deficient PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human p53 deficient PC3 cells after 72 hrs by celltiter-glo assay, IC50 = 30 μM.

20873740

SF539

Antiproliferative assay

72 hrs

Antiproliferative activity against human SF539 cells expressing p53 after 72 hrs by celltiter-glo assay, IC50 = 43 μM.

20873740

HCT15

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT15 cells expressing p53 after 72 hrs by celltiter-glo assay, IC50 = 48 μM.

20873740

Hep2

Anticancer assay

48 hrs

Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 0.3 μM.

21074444

A549

Anticancer assay

48 hrs

Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 2.4 μM.

21074444

HCT15

Anticancer assay

48 hrs

Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 3.6 μM.

21074444

502713

Anticancer assay

48 hrs

Anticancer activity against human 502713 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 4.6 μM.

21074444

DU145

Anticancer assay

48 hrs

Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 4.8 μM.

21074444

PC3

Anticancer assay

48 hrs

Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 12 μM.

21074444

IMR32

Anticancer assay

48 hrs

Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 18 μM.

21074444

MCF7

Cytotoxicity assay

3 days

Cytotoxicity against human MCF7 cells expressing wild type p53 and ras mutant after 3 days by SRB assay, IC50 = 4.32 μM.

21126804

Cytotoxicity assay

48 hrs

Cytotoxicity against human KB cells after 48 hrs by MTT assay, IC50 = 2.16 μM.

21131104

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 2.78 μM.

21131104

K562

Cytotoxicity assay

48 hrs

Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 38 μM.

21131104

Cytotoxicity assay

3 days

Cytotoxicity against human KB cells after 3 days by MTT assay, IC50 = 11.9 μM.

21144621

MGC803

Cytotoxicity assay

3 days

Cytotoxicity against human MGC803 cells after 3 days by MTT assay, IC50 = 12.6 μM.

21144621

CNE2

Cytotoxicity assay

3 days

Cytotoxicity against human CNE2 cells after 3 days by MTT assay, IC50 = 13.1 μM.

21144621

MCF7

Cytotoxicity assay

3 days

Cytotoxicity against human MCF7 cells after 3 days by MTT assay, IC50 = 15.2 μM.

21144621

L1210

Cytotoxicity assay

2 days

Cytotoxicity against mouse L1210 cells after 2 days by coulter counter analysis, IC50 = 0.56 μM.

21232828

HeLa

Cytotoxicity assay

4 days

Cytotoxicity against human HeLa cells after 4 days by coulter counter analysis, IC50 = 0.57 μM.

21232828

CEM

Cytotoxicity assay

3 days

Cytotoxicity against human CEM cells after 3 days by coulter counter analysis, IC50 = 14 μM.

21232828

HL60

Cytotoxicity assay

48 hrs

Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 9.5 μM.

21250700

A549

Cytotoxicity assay

48 hrs

Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 11.3 μM.

21250700

Cytotoxicity assay

72 hrs

Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 15.9 μM.

21273072

MDA-MB-231

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs, IC50 = 4.7 μM.

21295381

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs, IC50 = 9.6 μM.

21295381

L1210

Function assay

24 hrs

Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting, IC50 = 0.02 μM.

21330014

L1210

Function assay

24 hrs

Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting, IC50 = 0.06 μM.

21330014

FM3A

Cytostatic activity assay

2 days

Cytostatic activity against mouse FM3A cells after 2 days by coulter counting analysis, IC50 = 0.18 μM.

21330014

L1210

Function assay

4 hrs

Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting, IC50 = 0.22 μM.

21330014

L1210

Function assay

24 hrs

Inhibition of DNA synthesis in mouse L1210 cells assessed as [6-3H]2'-deoxyuridine incorporation in to DNA preincubated for 24 hrs by liquid scintillation counting, IC50 = 0.37 μM.

21330014

HeLa

Cytostatic activity assay

3 days

Cytostatic activity against human HeLa cells after 3 days by coulter counting analysis, IC50 = 0.45 μM.

21330014

L1210

Cytostatic activity assay

2 days

Cytostatic activity against mouse L1210 cells after 2 days by coulter counting analysis, IC50 = 0.56 μM.

21330014

L1210

Function assay

4 hrs

Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 hrs by liquid scintillation counting, IC50 = 0.6 μM.

21330014

L1210

Function assay

24 hrs

Inhibition of RNA synthesis in mouse L1210 cells assessed as [5-3H]uridine incorporation in to RNA preincubated for 24 hrs by liquid scintillation counting, IC50 = 4.9 μM.

21330014

L1210

Function assay

15 mins

Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 mins by liquid scintillation counting, IC50 = 7 μM.

21330014

CEM

Cytostatic activity assay

3 days

Cytostatic activity against human CEM cells after 3 days by coulter counting analysis, IC50 = 14 μM.

21330014

HL60

Cytotoxicity assay

48 hrs

Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 9.1 μM.

21381696

CEM

Cytotoxicity assay

72 hrs

Cytotoxicity against human CEM cells after 72 hrs by trypan blue assay, IC50 = 8 μM.

21439690

CEM

Cytotoxicity assay

48 hrs

Cytotoxicity against human CEM cells after 48 hrs by trypan blue assay, IC50 = 15 μM.

21439690

CEM

Cytotoxicity assay

72 hrs

Cytotoxicity against human CEM cells after 72 hrs by MTT assay, IC50 = 30 μM.

21439690

CEM

Cytotoxicity assay

48 hrs

Cytotoxicity against human CEM cells after 48 hrs by MTT assay, IC50 = 40 μM.

21439690

MIAPaCa2

Antiproliferative assay

72 hrs

Antiproliferative activity against human MIAPaCa2 cells after 72 hrs, IC50 = 7.4 μM.

21458113

COLO320

Antiproliferative assay

72 hrs

Antiproliferative activity against human COLO320 cells after 72 hrs, IC50 = 8.7 μM.

21458113

COLO320

Antiproliferative assay

48 hrs

Antiproliferative activity against human COLO320 cells after 48 hrs, IC50 = 10 μM.

21458113

MIAPaCa2

Antiproliferative assay

48 hrs

Antiproliferative activity against human MIAPaCa2 cells after 48 hrs, IC50 = 14 μM.

21458113

MCF7

Antitumor assay

72 hrs

Antitumor activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.54 μM.

21486694

EC9706

Antitumor assay

72 hrs

Antitumor activity against human EC9706 cells after 72 hrs by MTT assay, IC50 = 20.3 μM.

21486694

SPC-A1

Antitumor assay

72 hrs

Antitumor activity against human SPC-A1 cells after 72 hrs by MTT assay, IC50 = 26.92 μM.

21486694

PC3

Antitumor assay

72 hrs

Antitumor activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 29.3 μM.

21486694

HeLa

Antitumor assay

72 hrs

Antitumor activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 41.46 μM.

21486694

ZR-75-1

Growth inhibition assay

48 hrs

Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.3 μM.

21489802

A549

Growth inhibition assay

48 hrs

Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.4 μM.

21489802

COLO205

Growth inhibition assay

48 hrs

Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.8 μM.

21489802

MCF7

Growth inhibition assay

48 hrs

Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.8 μM.

21489802

Gurav

Growth inhibition assay

48 hrs

Growth inhibition of human Gurav cells after 48 hrs by sulforhodamine B assay, GI50 = 3.1 μM.

21489802

A2780

Growth inhibition assay

48 hrs

Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.5 μM.

21489802

HOP62

Growth inhibition assay

48 hrs

Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 4.1 μM.

21489802

Growth inhibition assay

48 hrs

Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay, GI50 = 5.2 μM.

21489802

DWD

Growth inhibition assay

48 hrs

Growth inhibition of human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 6.1 μM.

21489802

SiHa

Growth inhibition assay

48 hrs

Growth inhibition of human SiHa cells after 48 hrs by sulforhodamine B assay, GI50 = 6.3 μM.

21489802

PC3

Growth inhibition assay

48 hrs

Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay, GI50 = 12 μM.

21489802

SW620

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 3.38 μM.

21524829

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 10.31 μM.

21524829

MIAPaCa2

Antiproliferative assay

72 hrs

Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay, IC50 = 11.45 μM.

21524829

WI38

Antiproliferative assay

72 hrs

Antiproliferative activity against human WI38 cells after 72 hrs by MTT assay, IC50 = 18.5 μM.

21524829

SKBR3

Antiproliferative assay

72 hrs

Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay, IC50 = 38.25 μM.

21524829

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 42.01 μM.

21524829

PA1

Antiproliferative assay

48 hrs

Antiproliferative activity against human PA1 cells after 48 hrs by resazurin reduction test, IC50 = 5 μM.

21530016

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test, IC50 = 15 μM.

21530016

HeLa

Cytotoxicity assay

3 days

Cytotoxicity against human HeLa cells after 3 days by MTT assay, IC50 = 4 μM.

21612935

MG63

Cytotoxicity assay

3 days

Cytotoxicity against human MG63 cells after 3 days by MTT assay, IC50 = 8 μM.

21612935

L1210

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay, IC50 = 0.0000011 μM.

21640594

P388

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay, IC50 = 0.0000017 μM.

21640594

HL60

Cytotoxicity assay

72 hrs

Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.0000027 μM.

21640594

Cytotoxicity assay

72 hrs

Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 0.0000077 μM.

21640594

IEC-6

Cytotoxicity assay

6 days

Cytotoxicity against rat IEC-6 cells after 6 days by SRB colorimetric assay, IC50 = 0.66 μM.

21684047

MCF10A

Cytotoxicity assay

6 days

Cytotoxicity against human MCF10A cells after 6 days by SRB colorimetric assay, IC50 = 0.73 μM.

21684047

HT-29

Cytotoxicity assay

6 days

Cytotoxicity against human HT-29 cells after 6 days by SRB colorimetric assay, IC50 = 1.08 μM.

21684047

MCF7

Cytotoxicity assay

6 days

Cytotoxicity against human MCF7 cells after 6 days by SRB colorimetric assay, IC50 = 4.32 μM.

21684047

Cytotoxicity assay

3 days

Cytotoxicity against human KB cells after 3 days by MTT assay, IC50 = 12.5 μM.

21843939

HeLa

Cytostatic activity assay

72 hrs

Cytostatic activity against thymidine-kinase deficient human HeLa cells after 72 hrs by cell counting, IC50 = 0.23 μM.

21892829

L1210

Cytostatic activity assay

48 hrs

Cytostatic activity against thymidine-kinase deficient mouse L1210 cells after 48 hrs by cell counting, IC50 = 0.32 μM.

21892829

HeLa

Cytostatic activity assay

72 hrs

Cytostatic activity against human HeLa cells after 72 hrs by cell counting, IC50 = 0.54 μM.

21892829

CEM

Cytostatic activity assay

72 hrs

Cytostatic activity against thymidine-kinase deficient human CEM cells after 72 hrs by cell counting, IC50 = 12 μM.

21892829

CEM/0

Cytostatic activity assay

72 hrs

Cytostatic activity against human CEM/0 cells after 72 hrs by cell counting, IC50 = 18 μM.

21892829

A549

Cytotoxicity assay

3 days

Cytotoxicity against human A549 cells after 3 days by MTT assay, IC50 = 0.42 μM.

22000925

HepG2

Cytotoxicity assay

3 days

Cytotoxicity against human HepG2 cells after 3 days by MTT assay, IC50 = 2.7 μM.

22000925

BCG823

Cytotoxicity assay

3 days

Cytotoxicity against human BCG823 cells after 3 days by MTT assay, IC50 = 6.15 μM.

22000925

colon cancer cell

Cytotoxicity assay

48 hrs

Cytotoxicity against human colon cancer cells after 48 hrs by coulter counting, GI50 = 8.4 μM.

22056277

leukemia cell

Cytotoxicity assay

48 hrs

Cytotoxicity against human leukemia cells after 48 hrs by coulter counting, GI50 = 15.1 μM.

22056277

prostate cancer cell

Cytotoxicity assay

48 hrs

Cytotoxicity against human prostate cancer cells after 48 hrs by coulter counting, GI50 = 22.7 μM.

22056277

renal cancer cell

Cytotoxicity assay

48 hrs

Cytotoxicity against human renal cancer cells after 48 hrs by coulter counting, GI50 = 45.6 μM.

22056277

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 9.67 μM.

22079378

Antiproliferative assay

72 hrs

Antiproliferative activity against human KB cells after 72 hrs by MTT assay, IC50 = 9.85 μM.

22079378

GLC82

Antiproliferative assay

72 hrs

Antiproliferative activity against human GLC82 cells after 72 hrs by MTT assay, IC50 = 15.5 μM.

22079378

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 16.6 μM.

22079378

CNE2

Antiproliferative assay

72 hrs

Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay, IC50 = 17.2 μM.

22079378

HEK293

Cytotoxicity assay

2 days

Cytotoxicity against human HEK293 cells after 2 days by alamar blue assay, IC50 = 42.9 μM.

22093761

colon cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human colon cancer cells after 48 hrs by coulter counter method, GI50 = 8.4 μM.

22119151

leukemia cell

Growth inhibition assay

48 hrs

Growth inhibition of human leukemia cells after 48 hrs by coulter counter method, GI50 = 15.1 μM.

22119151

prostate cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human prostate cancer cells after 48 hrs by coulter counter method, GI50 = 22.7 μM.

22119151

renal cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human renal cancer cells after 48 hrs by coulter counter method, GI50 = 45.6 μM.

22119151

H460

Cytotoxicity assay

72 hrs

Cytotoxicity against human H460 cells after 72 hrs by MTT assay, IC50 = 3 μM.

22130132

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 4 μM.

22130132

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 14 μM.

22130132

A549

Cytotoxicity assay

24 hrs

Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50 = 5.64 μM.

22182926

QGY7701

Cytotoxicity assay

24 hrs

Cytotoxicity against human QGY7701 cells after 24 hrs by MTT assay, IC50 = 14.3 μM.

22182926

SW480

Cytotoxicity assay

24 hrs

Cytotoxicity against human SW480 cells after 24 hrs by MTT assay, IC50 = 15.71 μM.

22182926

HeLa

Cytotoxicity assay

24 hrs

Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 16.32 μM.

22182926

Cytotoxicity assay

72 hrs

Cytotoxicity against human KB cells after 72 hrs ny MTT assay, IC50 = 9 μM.

22200404

CNE2

Cytotoxicity assay

72 hrs

Cytotoxicity against human CNE2 cells after 72 hrs ny MTT assay, IC50 = 13.5 μM.

22200404

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 15.92 μM.

22209486

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 29 μM.

22304344

B16

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse B16 cells after 48 hrs by MTT assay, IC50 = 33 μM.

22304344

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 34 μM.

22304344

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 35 μM.

22304344

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 43 μM.

22304344

SW1990

Cytotoxicity assay

48 hrs

Cytotoxicity against human SW1990 cells after 48 hrs by MTT assay, IC50 = 45 μM.

22304344

Cytotoxicity assay

48 hrs

Cytotoxicity against human SR cells after 48 hrs by SRB assay, GI50 = 0.0238 μM.

22305543

NCI-H522

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H522 cells after 48 hrs by SRB assay, GI50 = 7.28 μM.

22305543

WHCO1

Antiproliferative assay

48 hrs

Antiproliferative activity against human WHCO1 cells after 48 hrs by MTT assay, IC50 = 7.9 μM.

22381354

HaCaT

Cytostatic activity assay

72 hrs

Cytostatic activity against human HaCaT cells after 72 hrs by MTT assay, IC50 = 0.3 μM.

22405290

L1210

Cytostatic activity assay

2 days

Cytostatic activity against mouse L1210 cells after 2 days by coulter counter analysis, IC50 = 0.49 μM.

22405290

HeLa

Cytostatic activity assay

3 days

Cytostatic activity against human HeLa cells after 3 days by coulter counter analysis, IC50 = 0.54 μM.

22405290

NCI-H460

Cytostatic activity assay

72 hrs

Cytostatic activity against human NCI-H460 cells after 72 hrs by MTT assay, IC50 = 3 μM.

22405290

HCT116

Cytostatic activity assay

72 hrs

Cytostatic activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 4 μM.

22405290

MCF7

Cytostatic activity assay

72 hrs

Cytostatic activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 15 μM.

22405290

CEM

Cytostatic activity assay

3 days

Cytostatic activity against human CEM cells after 3 days by coulter counter analysis, IC50 = 18 μM.

22405290

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 3.42 μM.

22405648

Bcap37

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay, IC50 = 5.33 μM.

22405648

SGC7901

Cytotoxicity assay

48 hrs

Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 7.11 μM.

22405648

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50 = 3.5 μM.

22409771

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay, IC50 = 5 μM.

22409771

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay, IC50 = 6 μM.

22409771

FOCUS

Cytotoxicity assay

72 hrs

Cytotoxicity against human FOCUS cells after 72 hrs by SRB assay, IC50 = 7.6 μM.

22409771

Mahlavu

Cytotoxicity assay

72 hrs

Cytotoxicity against human Mahlavu cells after 72 hrs by SRB assay, IC50 = 10 μM.

22409771

HuH7

Cytotoxicity assay

72 hrs

Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay, IC50 = 30.7 μM.

22409771

PC3

Antiproliferative assay

48 hrs

Antiproliferative activity against human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 2.1 μM.

22424614

MOLT4

Antiproliferative assay

48 hrs

Antiproliferative activity against human MOLT4 cells after 48 hrs by sulforhodamine B assay, IC50 = 3.2 μM.

22424614

MCF7

Antiproliferative assay

144 hrs

Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 144 hrs by crystal violet staining method, IC50 = 4.7 μM.

22450132

HT-29

Antiproliferative assay

144 hrs

Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 144 hrs by crystal violet staining method, IC50 = 7.3 μM.

22450132

MDA-MB-231

Antiproliferative assay

144 hrs

Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition after 144 hrs by crystal violet staining method, IC50 = 9.6 μM.

22450132

PC9

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC9 cells after 48 hrs by MTT assay, IC50 = 23.47 μM.

22483608

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 31.72 μM.

22483608

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 35.05 μM.

22483608

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 46.31 μM.

22483608

A375

Cytotoxicity assay

48 hrs

Cytotoxicity against human A375 cells after 48 hrs by MTT assay, IC50 = 46.55 μM.

22483608

SKHEP1

Growth inhibition assay

48 hrs

Growth inhibition of human SKHEP1 cells after 48 hrs by SRB assay, GI50 = 6.3 μM.

22512908

NCI-H460

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay, GI50 = 6.5 μM.

22512908

BxPC3

Growth inhibition assay

48 hrs

Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay, GI50 = 8.2 μM.

22512908

MSC

Growth inhibition assay

48 hrs

Growth inhibition of human MSC cells after 48 hrs by SRB assay, GI50 = 8.92 μM.

22512908

IGROV1

Growth inhibition assay

48 hrs

Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay, GI50 = 9.1 μM.

22512908

DU145

Growth inhibition assay

48 hrs

Growth inhibition of human DU145 cells after 48 hrs by SRB assay, GI50 = 9.37 μM.

22512908

HUVEC

Growth inhibition assay

48 hrs

Growth inhibition of HUVEC cells after 48 hrs by SRB assay, GI50 = 9.72 μM.

22512908

HCT116

Growth inhibition assay

48 hrs

Growth inhibition of human HCT116 cells after 48 hrs by SRB assay, GI50 = 9.9 μM.

22512908

MCF7

Growth inhibition assay

48 hrs

Growth inhibition of human MCF7 cells after 48 hrs by SRB assay, GI50 = 9.9 μM.

22512908

OVCAR5

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay, GI50 = 20 μM.

22512908

HCT15

Growth inhibition assay

48 hrs

Growth inhibition of human HCT15 cells after 48 hrs by SRB assay, GI50 = 21 μM.

22512908

PC3

Growth inhibition assay

48 hrs

Growth inhibition of human PC3 cells after 48 hrs by SRB assay, GI50 = 21 μM.

22512908

MIAPaCa2

Growth inhibition assay

48 hrs

Growth inhibition of human MIAPaCa2 cells after 48 hrs by SRB assay, GI50 = 30 μM.

22512908

K562

Cytotoxicity assay

48 hrs

Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 2.1 μM.

22537362

Cytotoxicity assay

48 hrs

Cytotoxicity against human KB cells after 48 hrs by MTT assay, IC50 = 6.8 μM.

22537362

KB/VCR

Cytotoxicity assay

48 hrs

Cytotoxicity against human KB/VCR cells after 48 hrs by MTT assay, IC50 = 33.4 μM.

22537362

SW620

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 6.68 μM.

22555152

MIAPaCa2

Antiproliferative assay

72 hrs

Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay, IC50 = 11.67 μM.

22555152

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 14.93 μM.

22555152

WI38

Antiproliferative assay

72 hrs

Antiproliferative activity against human WI38 cells after 72 hrs by MTT assay, IC50 = 24.66 μM.

22555152

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells by after 48 hrs by MTT assay, IC50 = 5.64 μM.

22579780

SGC7901

Cytotoxicity assay

48 hrs

Cytotoxicity against human SGC7901 cells by after 48 hrs by MTT assay, IC50 = 6.04 μM.

22579780

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells by after 48 hrs by MTT assay, IC50 = 13.65 μM.

22579780

QGY7701

Cytotoxicity assay

48 hrs

Cytotoxicity against human QGY7701 cells by after 48 hrs by MTT assay, IC50 = 14.3 μM.

22579780

SW480

Cytotoxicity assay

48 hrs

Cytotoxicity against human SW480 cells by after 48 hrs by MTT assay, IC50 = 15.71 μM.

22579780

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells by after 48 hrs by MTT assay, IC50 = 16.32 μM.

22579780

L02

Cytotoxicity assay

48 hrs

Cytotoxicity against human L02 cells by after 48 hrs by MTT assay, IC50 = 46.57 μM.

22579780

SH-SY5Y

Cytotoxicity assay

72 hrs

Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay, IC50 = 1.09 μM.

22687745

L929

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay, IC50 = 1.38 μM.

22687745

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 8.83 μM.

22687745

DU145

Cytotoxicity assay

72 hrs

Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50 = 12.32 μM.

22687745

SGC7901

Cytotoxicity assay

72 hrs

Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 14.49 μM.

22687745

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 15.99 μM.

22687745

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 32.22 μM.

22687745

NCI-H460

Cytotoxicity assay

72 hrs

Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay, IC50 = 2.4 μM.

22727445

BGC823

Cytotoxicity assay

72 hrs

Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay, IC50 = 4.5 μM.

22727445

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 4.8 μM.

22727445

SGC7901

Cytotoxicity assay

72 hrs

Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 6.3 μM.

22727445

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 12.5 μM.

22727445

Cytotoxicity assay

72 hrs

Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 8.28 μM.

22749192

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 14.2 μM.

22749192

CNE2

Cytotoxicity assay

72 hrs

Cytotoxicity against human CNE2 cells after 72 hrs by MTT assay, IC50 = 15.1 μM.

22749192

GLC82

Cytotoxicity assay

72 hrs

Cytotoxicity against human GLC82 cells after 72 hrs by MTT assay, IC50 = 17.4 μM.

22749192

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 18.5 μM.

22749192

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by crystal violet staining method, IC50 = 4.7 μM.

22765897

HT-29

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT-29 cells after 72 hrs by crystal violet staining method, IC50 = 7.3 μM.

22765897

MDA-MB-231

Antiproliferative assay

72 hrs

Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by crystal violet staining method, IC50 = 9.6 μM.

22765897

PC3M

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3M cells after 48 hrs by MTT assay, IC50 = 22.63 μM.

22809558

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 35.41 μM.

22809558

MKN45

Cytotoxicity assay

48 hrs

Cytotoxicity against human MKN45 cells after 48 hrs by MTT assay, IC50 = 41.73 μM.

22809558

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 46.83 μM.

22809558

LoVo

Antiproliferative assay

48 hrs

Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay, IC50 = 3.3 μM.

22840493

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 12.8 μM.

22840493

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 16.2 μM.

22840493

IOSE-144

Antiproliferative assay

48 hrs

Antiproliferative activity against human IOSE-144 cells after 48 hrs by MTT assay, IC50 = 25.6 μM.

22840493

CAMA1

Cytotoxicity assay

72 hrs

Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay, IC50 = 1.28 μM.

22867707

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay, IC50 = 3.5 μM.

22867707

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay, IC50 = 5.7 μM.

22867707

FOCUS

Cytotoxicity assay

72 hrs

Cytotoxicity against human FOCUS cells incubated for 72 hrs by SRB assay, IC50 = 7.69 μM.

22867707

T47D

Cytotoxicity assay

72 hrs

Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay, IC50 = 8.91 μM.

22867707

Cytotoxicity assay

72 hrs

Cytotoxicity against human MV cells incubated for 72 hrs by SRB assay, IC50 = 9.97 μM.

22867707

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay, IC50 = 18.7 μM.

22867707

MFE296

Cytotoxicity assay

72 hrs

Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay, IC50 = 30.68 μM.

22867707

HuH7

Cytotoxicity assay

72 hrs

Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay, IC50 = 30.7 μM.

22867707

BT20

Cytotoxicity assay

72 hrs

Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay, IC50 = 47.3 μM.

22867707

COLO320

Cytotoxicity assay

72 hrs

Cytotoxicity against human COLO320 cells assessed as cell viability after 72 hrs by WST-1 assay, IC50 = 12.5 μM.

22955095

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by crystal violet staining, IC50 = 4.7 μM.

22959205

HT-29

Cytotoxicity assay

72 hrs

Cytotoxicity against human HT-29 cells after 72 hrs by crystal violet staining, IC50 = 7.3 μM.

22959205

MDA-MB-231

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDA-MB-231 cells after 72 hrs by crystal violet staining, IC50 = 9.6 μM.

22959205

HL60

Cytotoxicity assay

72 hrs

Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.06 μM.

22959518

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 0.28 μM.

22959518

U937

Cytotoxicity assay

72 hrs

Cytotoxicity against human U937 cells after 72 hrs by MTT assay, IC50 = 1.07 μM.

22959518

colon cancer

Antiproliferative assay

48 hrs

Antiproliferative activity against human colon cancer cells after 48 hrs by cell counting analysis, GI50 = 8.4 μM.

22995621

leukemia

Antiproliferative assay

48 hrs

Antiproliferative activity against human leukemia cells after 48 hrs by cell counting analysis, GI50 = 15.1 μM.

22995621

prostate cancer

Antiproliferative assay

48 hrs

Antiproliferative activity against human prostate cancer cells after 48 hrs by cell counting analysis, GI50 = 22.7 μM.

22995621

renal cancer

Antiproliferative assay

48 hrs

Antiproliferative activity against human renal cancer cells after 48 hrs by cell counting analysis, GI50 = 45.6 μM.

22995621

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 9.5 μM.

23002924

MNK45

Cytotoxicity assay

48 hrs

Cytotoxicity against human MNK45 cells after 48 hrs by MTT assay, IC50 = 12 μM.

23002924

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT method, IC50 = 1.3 μM.

23018096

BGC823

Antiproliferative assay

48 hrs

Antiproliferative activity against human BGC823 cells after 48 hrs by MTT method, IC50 = 1.52 μM.

23018096

SW1116

Antiproliferative assay

48 hrs

Antiproliferative activity against human SW1116 cells after 48 hrs by MTT method, IC50 = 2.41 μM.

23018096

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells after 48 hrs by MTT method, IC50 = 3.25 μM.

23018096

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed cell viability after 48 hrs by SRB assay, IC50 = 4.21 μM.

23044370

HT1080

Cytotoxicity assay

48 hrs

Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay, IC50 = 15.2 μM.

23067549

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 36.4 μM.

23067549

MSC

Growth inhibition assay

48 hrs

Growth inhibition of human MSC cells after 48 hrs by SRB assay, GI50 = 0.001 μM.

23094992

MSC

Growth inhibition assay

48 hrs

Growth inhibition of human MSC cells after 48 hrs by SRB assay, TGI = 0.001 μM.

23094992

BxPC3

Growth inhibition assay

48 hrs

Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay, GI50 = 0.0029 μM.

23094992

HUVEC

Growth inhibition assay

48 hrs

Growth inhibition of human HUVEC cells after 48 hrs by SRB assay, GI50 = 0.0036 μM.

23094992

SKHEP1

Growth inhibition assay

48 hrs

Growth inhibition of human SKHEP1 cells after 48 hrs by SRB assay, GI50 = 0.0076 μM.

23094992

IGROV1

Growth inhibition assay

48 hrs

Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay, GI50 = 0.00812 μM.

23094992

BxPC3

Growth inhibition assay

48 hrs

Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay, TGI = 0.0084 μM.

23094992

HCT116

Growth inhibition assay

48 hrs

Growth inhibition of human HCT116 cells after 48 hrs by SRB assay, GI50 = 0.0088 μM.

23094992

PC3

Growth inhibition assay

48 hrs

Growth inhibition of human PC3 cells after 48 hrs by SRB assay, GI50 = 0.01045 μM.

23094992

MCF7

Growth inhibition assay

48 hrs

Growth inhibition of human MCF7 cells after 48 hrs by SRB assay, GI50 = 0.0145 μM.

23094992

DU145

Growth inhibition assay

48 hrs

Growth inhibition of human DU145 cells after 48 hrs by SRB assay, GI50 = 0.02 μM.

23094992

HCT15

Growth inhibition assay

48 hrs

Growth inhibition of human HCT15 cells after 48 hrs by SRB assay, GI50 = 0.0211 μM.

23094992

OVCAR5

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay, GI50 = 0.0264 μM.

23094992

MIAPaCa2

Growth inhibition assay

48 hrs

Growth inhibition of human MIAPaCa2 cells after 48 hrs by SRB assay, GI50 = 0.0306 μM.

23094992

NHDF

Growth inhibition assay

48 hrs

Growth inhibition of human NHDF cells after 48 hrs by SRB assay, GI50 = 0.06202 μM.

23094992

U251

Growth inhibition assay

48 hrs

Growth inhibition of human U251 cells after 48 hrs by SRB assay, GI50 = 0.0696 μM.

23094992

NHDF

Growth inhibition assay

48 hrs

Growth inhibition of human NHDF cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

MIAPaCa2

Growth inhibition assay

48 hrs

Growth inhibition of human MIAPaCa2 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

HUVEC

Growth inhibition assay

48 hrs

Growth inhibition of human HUVEC cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

OVCAR5

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

HL-60(TB)

Growth inhibition assay

48 hrs

Growth inhibition of human HL-60(TB) cells after 48 hrs by SRB assay, GI50 = 0.1 μM.

23094992

HL-60(TB)

Growth inhibition assay

48 hrs

Growth inhibition of human HL-60(TB) cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

U251

Growth inhibition assay

48 hrs

Growth inhibition of human U251 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

DU145

Growth inhibition assay

48 hrs

Growth inhibition of human DU145 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

SKHEP1

Growth inhibition assay

48 hrs

Growth inhibition of human SKHEP1 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

MCF7

Growth inhibition assay

48 hrs

Growth inhibition of human MCF7 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

HCT15

Growth inhibition assay

48 hrs

Growth inhibition of human HCT15 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

IGROV1

Growth inhibition assay

48 hrs

Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

PC3

Growth inhibition assay

48 hrs

Growth inhibition of human PC3 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

HCT116

Growth inhibition assay

48 hrs

Growth inhibition of human HCT116 cells after 48 hrs by SRB assay, TGI = 0.1 μM.

23094992

HepG2

Cytotoxicity assay

24 hrs

Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50 = 29.87 μM.

23202484

PA1

Cytotoxicity assay

24 hrs

Cytotoxicity against human PA1 cells after 24 hrs by MTT assay, IC50 = 39.5 μM.

23202484

HCT15

Cytotoxicity assay

24 hrs

Cytotoxicity against human HCT15 cells after 24 hrs by MTT assay, IC50 = 45.01 μM.

23202484

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 17.2 μM.

23279864

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 21.9 μM.

23279864

SGC7901

Cytotoxicity assay

72 hrs

Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 28.5 μM.

23279864

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells assessed as inhibition cell proliferation after 48 hrs by Sulforhodamine B assay, IC50 = 3.56 μM.

23305919

B16F10

Anticancer assay

48 hrs

Anticancer activity against mouse B16F10 cells assessed as cell survival measured after 48 hrs by MTT assay, IC50 = 21.41 μM.

23312949

SGC7901

Anticancer assay

48 hrs

Anticancer activity against human SGC7901 cells assessed as cell survival measured after 48 hrs by MTT assay, IC50 = 46.35 μM.

23312949

HeLa

Antitumor assay

48 hrs

Antitumor activity against human HeLa cells assessed as growth inhibition measured after 48 hrs by MTT assay, IC50 = 14.78 μM.

23313635

A549

Growth inhibition assay

48 hrs

Growth inhibition of human A549 cells after 48 hrs by MTT assay, IC50 = 5.64 μM.

23353737

QGY7701

Growth inhibition assay

48 hrs

Growth inhibition of human QGY7701 cells after 48 hrs by MTT assay, IC50 = 14.3 μM.

23353737

HuH7

Growth inhibition assay

48 hrs

Growth inhibition of human HuH7 cells after 48 hrs by MTT assay, IC50 = 15.85 μM.

23353737

HeLa

Growth inhibition assay

48 hrs

Growth inhibition of human HeLa cells after 48 hrs by MTT assay, IC50 = 16.32 μM.

23353737

L02

Growth inhibition assay

48 hrs

Growth inhibition of human L02 cells after 48 hrs by MTT assay, IC50 = 46.57 μM.

23353737

EC109

Cytotoxicity assay

72 hrs

Cytotoxicity against human EC109 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 3.34 μM.

23353743

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 7.01 μM.

23353743

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 7.54 μM.

23353743

PC3

Cytotoxicity assay

72 hrs

Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 27.07 μM.

23353743

colon cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human colon cancer cells after 48 hrs by sulphorhodamine B assay, GI50 = 8.4 μM.

23474899

leukemia

Cytotoxicity assay

48 hrs

Cytotoxicity against human leukemia cells after 48 hrs by sulphorhodamine B assay, GI50 = 15.1 μM.

23474899

prostate cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human prostate cancer cells after 48 hrs by sulphorhodamine B assay, GI50 = 22.7 μM.

23474899

renal cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human renal cancer cells after 48 hrs by sulphorhodamine B assay, GI50 = 45.6 μM.

23474899

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 16.7 μM.

23490159

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 22.8 μM.

23490159

SGC7901

Cytotoxicity assay

48 hrs

Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 28.9 μM.

23490159

THP1

Antiproliferative assay

48 hrs

Antiproliferative activity against human THP1 cells after 48 hrs by sulforhodamine B assay, IC50 = 1 μM.

23501113

PC3

Antiproliferative assay

48 hrs

Antiproliferative activity against human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 2.2 μM.

23501113

Hep2

Antiproliferative assay

48 hrs

Antiproliferative activity against human Hep2 cells after 48 hrs by sulforhodamine B assay, IC50 = 4.5 μM.

23501113

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay, IC50 = 4.9 μM.

23501113

K562

Cytotoxicity assay

72 hrs

Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50 = 28 μM.

23535322

CEM

Cytotoxicity assay

72 hrs

Cytotoxicity against human CEM cells after 72 hrs by MTT assay, IC50 = 32 μM.

23535322

A375-S2

Cytotoxicity assay

48 hrs

Cytotoxicity against human A375-S2 cells after 48 hrs by MTT assay, IC50 = 6.67 μM.

23558238

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 7.34 μM.

23558238

HL60

Cytotoxicity assay

48 hrs

Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 10.05 μM.

23558238

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 11.5 μM.

23558238

K562

Cytotoxicity assay

48 hrs

Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 23.55 μM.

23558238

U937

Cytotoxicity assay

48 hrs

Cytotoxicity against human U937 cells after 48 hrs by MTT assay, IC50 = 23.93 μM.

23558238

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 27.76 μM.

23558238

HT1080

Cytotoxicity assay

48 hrs

Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay, IC50 = 35.62 μM.

23558238

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 40.34 μM.

23558238

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 44.05 μM.

23558238

EC9706

Cytotoxicity assay

72 hrs

Cytotoxicity against human EC9706 cells after 72 hrs by MTT assay, IC50 = 0.32 μM.

23644193

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 7.14 μM.

23644193

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.33 μM.

23644193

SMMC7721

Cytotoxicity assay

72 hrs

Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 26.71 μM.

23644193

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B assay, IC50 = 4.52 μM.

23644215

HT-29

Cytotoxicity assay

48 hrs

Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay, IC50 = 6.35 μM.

23644215

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 3.52 μM.

23665106

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 5.53 μM.

23665106

HT-29

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, IC50 = 24.5 μM.

23665106

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 32.18 μM.

23665106

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 43.71 μM.

23665106

colon cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human colon cancer cells after 48 hrs by coulter counter analysis, GI50 = 8.4 μM.

23683592

leukemia

Cytotoxicity assay

48 hrs

Cytotoxicity against human leukemia cells after 48 hrs by coulter counter analysis, GI50 = 15.1 μM.

23683592

prostate cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human prostate cancer cells after 48 hrs by coulter counter analysis, GI50 = 22.7 μM.

23683592

renal cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human renal cancer cells after 48 hrs by coulter counter analysis, GI50 = 45.6 μM.

23683592

SH-SY5Y

Cytotoxicity assay

72 hrs

Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay, IC50 = 0.97 μM.

23685571

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 3.24 μM.

23685571

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 8.71 μM.

23685571

Vero

Cytotoxicity assay

72 hrs

Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay, IC50 = 9.71 μM.

23685571

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 10.14 μM.

23685571

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 24.96 μM.

23685571

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells expressing SKP2 after 72 hrs by MTT assay, IC50 = 27.07 μM.

23735281

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells expressing PCDNA after 72 hrs by MTT assay, IC50 = 31.44 μM.

23735281

COLO320DM

Cytotoxicity assay

48 hrs

Cytotoxicity against human COLO320DM cells after 48 hrs by MTT assay, IC50 = 2 μM.

23792352

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 3.4 μM.

23792763

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 3.6 μM.

23792763

SW480

Cytotoxicity assay

72 hrs

Cytotoxicity against human SW480 cells after 72 hrs by MTT assay, IC50 = 8.1 μM.

23792763

MDA-MB-435S

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDA-MB-435S cells after 72 hrs by MTT assay, IC50 = 14.5 μM.

23792763

LM7

Cytotoxicity assay

72 hrs

Cytotoxicity against human LM7 cells after 72 hrs by MTT assay, IC50 = 18.6 μM.

23792763

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 6.92 μM.

23792764

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.54 μM.

23792764

SMMC7721

Cytotoxicity assay

72 hrs

Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 9.78 μM.

23792764

EC109

Cytotoxicity assay

72 hrs

Cytotoxicity against human EC109 cells after 72 hrs by MTT assay, IC50 = 10.61 μM.

23792764

PC3

Cytotoxicity assay

72 hrs

Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50 = 24.76 μM.

23792764

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 5 μM.

23800391

Vero

Antiproliferative assay

48 hrs

Antiproliferative activity against african green monkey Vero cells after 48 hrs by MTT assay, IC50 = 8 μM.

23800391

WI38

Antiproliferative assay

48 hrs

Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay, IC50 = 10 μM.

23800391

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 10 μM.

23800391

HL60

Cytotoxicity assay

48 hrs

Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 22.3 μM.

23867385

H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human H460 cells after 48 hrs by MTT assay, IC50 = 26.7 μM.

23867385

Cytotoxicity assay

72 hrs

Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50 = 4.84 μM.

23867603

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by SRB assay, IC50 = 6.23 μM.

23867603

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50 = 6.53 μM.

23867603

OVCAR3

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.01 μM.

23887055

Growth inhibition assay

48 hrs

Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay, GI50 = 0.02 μM.

23887055

RPMI8226

Growth inhibition assay

48 hrs

Growth inhibition of human RPMI8226 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.04 μM.

23887055

MALME-3M

Growth inhibition assay

48 hrs

Growth inhibition of human MALME-3M cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05 μM.

23887055

HCC2998

Growth inhibition assay

48 hrs

Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05 μM.

23887055

NCI-H460

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.05 μM.

23887055

SF539

Growth inhibition assay

48 hrs

Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.06 μM.

23887055

MCF7

Growth inhibition assay

48 hrs

Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07 μM.

23887055

CAKI-1

Growth inhibition assay

48 hrs

Growth inhibition of human CAKI-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07 μM.

23887055

MDA-MB-435

Growth inhibition assay

48 hrs

Growth inhibition of human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.07 μM.

23887055

HCT15

Growth inhibition assay

48 hrs

Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.11 μM.

23887055

COLO205

Growth inhibition assay

48 hrs

Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.15 μM.

23887055

HT-29

Growth inhibition assay

48 hrs

Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.17 μM.

23887055

A549/ATCC

Growth inhibition assay

48 hrs

Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay, GI50 = 0.18 μM.

23887055

KM12

Growth inhibition assay

48 hrs

Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.21 μM.

23887055

HCT116

Growth inhibition assay

48 hrs

Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.22 μM.

23887055

SF295

Growth inhibition assay

48 hrs

Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.22 μM.

23887055

LOXIMVI

Growth inhibition assay

48 hrs

Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay, GI50 = 0.24 μM.

23887055

ACHN

Growth inhibition assay

48 hrs

Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay, GI50 = 0.29 μM.

23887055

NCI-ADR-RES

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay, GI50 = 0.31 μM.

23887055

NCI-H23

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.33 μM.

23887055

A498

Growth inhibition assay

48 hrs

Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.35 μM.

23887055

MOLT4

Growth inhibition assay

48 hrs

Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.35 μM.

23887055

DU145

Growth inhibition assay

48 hrs

Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.36 μM.

23887055

HOP62

Growth inhibition assay

48 hrs

Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.39 μM.

23887055

SK-MEL-5

Growth inhibition assay

48 hrs

Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.46 μM.

23887055

SN12C

Growth inhibition assay

48 hrs

Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay, GI50 = 0.49 μM.

23887055

UACC62

Growth inhibition assay

48 hrs

Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.52 μM.

23887055

786-0

Growth inhibition assay

48 hrs

Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.72 μM.

23887055

U251

Growth inhibition assay

48 hrs

Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.9 μM.

23887055

SW620

Growth inhibition assay

48 hrs

Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.92 μM.

23887055

M14

Growth inhibition assay

48 hrs

Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.98 μM.

23887055

SK-MEL-28

Growth inhibition assay

48 hrs

Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.03 μM.

23887055

TK10

Growth inhibition assay

48 hrs

Growth inhibition of human TK10 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.12 μM.

23887055

IGROV1

Growth inhibition assay

48 hrs

Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.22 μM.

23887055

UO31

Growth inhibition assay

48 hrs

Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.42 μM.

23887055

SF268

Growth inhibition assay

48 hrs

Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.62 μM.

23887055

OVCAR8

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.74 μM.

23887055

HL-60(TB)

Growth inhibition assay

48 hrs

Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay, GI50 = 2.3 μM.

23887055

PC3

Growth inhibition assay

48 hrs

Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.36 μM.

23887055

RXF393

Growth inhibition assay

48 hrs

Growth inhibition of human RXF393 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.61 μM.

23887055

UACC257

Growth inhibition assay

48 hrs

Growth inhibition of human UACC257 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.55 μM.

23887055

K562

Growth inhibition assay

48 hrs

Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.58 μM.

23887055

SNB19

Growth inhibition assay

48 hrs

Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.81 μM.

23887055

OVCAR4

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay, GI50 = 4.43 μM.

23887055

MDA-MB-231

Growth inhibition assay

48 hrs

Growth inhibition of human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay, GI50 = 6.6 μM.

23887055

NCI-H522

Growth inhibition assay

48 hrs

Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay, GI50 = 7.27 μM.

23887055

T47D

Growth inhibition assay

48 hrs

Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay, GI50 = 8.12 μM.

23887055

Hs 578T

Growth inhibition assay

48 hrs

Growth inhibition of human Hs 578T cells after 48 hrs by sulforhodamine B assay, GI50 = 9.77 μM.

23887055

CCRF-CEM

Growth inhibition assay

48 hrs

Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay, GI50 = 9.79 μM.

23887055

BT549

Growth inhibition assay

48 hrs

Growth inhibition of human BT549 cells after 48 hrs by sulforhodamine B assay, GI50 = 10.6 μM.

23887055

OVCAR5

Growth inhibition assay

48 hrs

Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay, GI50 = 10.9 μM.

23887055

SKOV3

Growth inhibition assay

48 hrs

Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay, GI50 = 21.8 μM.

23887055

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 5.62 μM.

23920246

SGC7901

Cytotoxicity assay

48 hrs

Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 6.04 μM.

23920246

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 13.65 μM.

23920246

QGY7701

Cytotoxicity assay

48 hrs

Cytotoxicity against human QGY7701 cells after 48 hrs by MTT assay, IC50 = 14.3 μM.

23920246

SW480

Cytotoxicity assay

48 hrs

Cytotoxicity against human SW480 cells after 48 hrs by MTT assay, IC50 = 15.71 μM.

23920246

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 16.52 μM.

23920246

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by SRB assay, GI50 = 3.6 μM.

23964677

SKOV3

Cytotoxicity assay

48 hrs

Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay, IC50 = 24.43 μM.

23988357

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 29.98 μM.

23988357

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 34.33 μM.

23988357

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 44.04 μM.

23988357

leukemia

Cytotoxicity assay

48 hrs

Cytotoxicity against human leukemia cells after 48 hrs by SRB assay, GI50 = 1.51 μM.

23994328

colon cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human colon cancer cells after 48 hrs by SRB assay, GI50 = 8.4 μM.

23994328

prostate cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human prostate cancer cells after 48 hrs by SRB assay, GI50 = 22.7 μM.

23994328

renal cancer

Cytotoxicity assay

48 hrs

Cytotoxicity against human renal cancer cells after 48 hrs by SRB assay, GI50 = 45.6 μM.

23994328

A375-S2

Growth inhibition assay

48 hrs

Growth inhibition against human A375-S2 cells after 48 hrs by MTT assay, IC50 = 6.67 μM.

23999046

HeLa

Growth inhibition assay

48 hrs

Growth inhibition against human HeLa cells after 48 hrs by MTT assay, IC50 = 7.34 μM.

23999046

HL60

Growth inhibition assay

48 hrs

Growth inhibition against human HL60 cells after 48 hrs by MTT assay, IC50 = 10.05 μM.

23999046

MCF7

Growth inhibition assay

48 hrs

Growth inhibition against human MCF7 cells after 48 hrs by MTT assay, IC50 = 11.5 μM.

23999046

K562

Growth inhibition assay

48 hrs

Growth inhibition against human K562 cells after 48 hrs by MTT assay, IC50 = 23.55 μM.

23999046

U937

Growth inhibition assay

48 hrs

Growth inhibition against human U937 cells after 48 hrs by MTT assay, IC50 = 23.93 μM.

23999046

HCT116

Growth inhibition assay

48 hrs

Growth inhibition against human HCT116 cells after 48 hrs by MTT assay, IC50 = 27.76 μM.

23999046

HT1080

Growth inhibition assay

48 hrs

Growth inhibition against human HT1080 cells after 48 hrs by MTT assay, IC50 = 35.62 μM.

23999046

HepG2

Growth inhibition assay

48 hrs

Growth inhibition against human HepG2 cells after 48 hrs by MTT assay, IC50 = 40.34 μM.

23999046

A549

Growth inhibition assay

48 hrs

Growth inhibition against human A549 cells after 48 hrs by MTT assay, IC50 = 44.05 μM.

23999046

QSG7701

Cytotoxicity assay

48 hrs

Cytotoxicity against human QSG7701 cells after 48 hrs by CCK-8 assay, IC50 = 0.6 μM.

24013415

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by CCK-8 assay, IC50 = 12.48 μM.

24013415

SMMC7721

Cytotoxicity assay

48 hrs

Cytotoxicity against human SMMC7721 cells after 48 hrs by CCK-8 assay, IC50 = 14.55 μM.

24013415

QGY7703

Cytotoxicity assay

48 hrs

Cytotoxicity against human QGY7703 cells after 48 hrs by CCK-8 assay, IC50 = 15.66 μM.

24013415

Hep

Cytotoxicity assay

48 hrs

Cytotoxicity against human Hep cells after 48 hrs by SRB assay, IC50 = 0.5 μM.

24056146

IMR32

Cytotoxicity assay

48 hrs

Cytotoxicity against human IMR32 cells after 48 hrs by SRB assay, IC50 = 1.3 μM.

24056146

A549

Cytotoxicity assay

24 hrs

Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50 = 1.1 μM.

24060486

HeLa

Cytotoxicity assay

24 hrs

Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 1.1 μM.

24060486

MCF7

Cytotoxicity assay

24 hrs

Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay, IC50 = 1.2 μM.

24060486

DU145

Cytotoxicity assay

24 hrs

Cytotoxicity against human DU145 cells after 24 hrs by MTT assay, IC50 = 1.3 μM.

24060486

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 6.92 μM.

24077182

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 7.54 μM.

24077182

SMMC7721

Cytotoxicity assay

72 hrs

Cytotoxicity against human SMMC7721 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 9.78 μM.

24077182

EC109

Cytotoxicity assay

72 hrs

Cytotoxicity against human EC109 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 10.61 μM.

24077182

PC3

Cytotoxicity assay

72 hrs

Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 24.76 μM.

24077182

SKOV3

Cytotoxicity assay

3 days

Cytotoxicity against human SKOV3 cells after 3 days by MTT assay, IC50 = 24.43 μM.

24095745

HepG2

Cytotoxicity assay

3 days

Cytotoxicity against human HepG2 cells after 3 days by MTT assay, IC50 = 29.98 μM.

24095745

A549

Cytotoxicity assay

3 days

Cytotoxicity against human A549 cells after 3 days by MTT assay, IC50 = 34.33 μM.

24095745

NCI-H460

Cytotoxicity assay

3 days

Cytotoxicity against human NCI-H460 cells after 3 days by MTT assay, IC50 = 44.04 μM.

24095745

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 3.68 μM.

24119869

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 4.35 μM.

24119869

Bcap37

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay, IC50 = 5.58 μM.

24119869

SGC7901

Cytotoxicity assay

48 hrs

Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 7.37 μM.

24119869

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 8.32 μM.

24211021

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 15.32 μM.

24211021

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 19.45 μM.

24211021

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 20.13 μM.

24211021

NCI-H460

Cytotoxicity assay

72 hrs

Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay, IC50 = 23.32 μM.

24211021

SW1116

Cytotoxicity assay

48 hrs

Cytotoxicity against human SW1116 cells after 48 hrs by MTT assay, IC50 = 5.26 μM.

24286761

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 7.43 μM.

24286761

BGC823

Cytotoxicity assay

48 hrs

Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay, IC50 = 7.48 μM.

24286761

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 9.79 μM.

24286761

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 3.5 μM.

24332497

B16

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse B16 cells after 48 hrs by MTT assay, IC50 = 4.2 μM.

24332497

ME180

Cytotoxicity assay

48 hrs

Cytotoxicity against human ME180 cells after 48 hrs by MTT assay, IC50 = 4.9 μM.

24332497

A549

Cytotoxicity assay

4 days

Cytotoxicity against human A549 cells after 4 days by MTT assay, IC50 = 3.1 μM.

24359303

Bel7402

Cytotoxicity assay

4 days

Cytotoxicity against human Bel7402 cells after 4 days by MTT assay, IC50 = 5.5 μM.

24359303

Cytotoxicity assay

4 days

Cytotoxicity against human KB cells after 4 days by MTT assay, IC50 = 8.1 μM.

24359303

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 5.78 μM.

24378217

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 29.98 μM.

24378217

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 35.34 μM.

24378217

CNE

Cytotoxicity assay

48 hrs

Cytotoxicity against human CNE cells after 48 hrs by MTT assay, IC50 = 40.21 μM.

24378217

SPCA2

Cytotoxicity assay

48 hrs

Cytotoxicity against human SPCA2 cells after 48 hrs by MTT assay, IC50 = 42.2 μM.

24378217

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells after 48 hrs by MTT assay, IC50 = 14.3 μM.

24534537

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells after 48 hrs by trypan blue exclusion assay, IC50 = 14.3 μM.

24534537

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells after 48 hrs by MTT assay, IC50 = 15.7 μM.

24534537

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells after 48 hrs by LDH release assay, IC50 = 15.8 μM.

24534537

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells after 48 hrs by LDH release assay, IC50 = 16.3 μM.

24534537

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells after 48 hrs by trypan blue exclusion assay, IC50 = 16.4 μM.

24534537

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.3 μM.

24547794

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 7.6 μM.

24547794

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 24.43 μM.

24565905

SKOV3

Cytotoxicity assay

48 hrs

Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay, IC50 = 24.43 μM.

24565905

Bel7404

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bel7404 cells after 48 hrs by MTT assay, IC50 = 26.8 μM.

24565905

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 26.98 μM.

24565905

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 36.04 μM.

24565905

H3347

Cytotoxicity assay

72 hrs

Cytotoxicity against human H3347 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay, IC50 = 11.64 μM.

24583355

HT-29

Cytotoxicity assay

72 hrs

Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay, IC50 = 24.87 μM.

24583355

DLD1

Cytotoxicity assay

72 hrs

Cytotoxicity against human DLD1 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay, IC50 = 29.14 μM.

24583355

L1210

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse L1210 cells assessed as reduction in cell number after 48 hrs by cell counting assay, IC50 = 0.33 μM.

24631358

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells assessed as reduction in cell number after 72 hrs by cell counting assay, IC50 = 0.54 μM.

24631358

CCRF-CEM

Cytotoxicity assay

72 hrs

Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell number after 72 hrs by cell counting assay, IC50 = 18 μM.

24631358

HeLa

Cytotoxicity assay

24 hrs

Cytotoxicity against human HeLa cells assessed as growth inhibition after 24 hrs by MTT assay, IC50 = 1.8 μM.

24641975

MCF7

Cytotoxicity assay

24 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition after 24 hrs by MTT assay, IC50 = 1.8 μM.

24641975

A549

Cytotoxicity assay

24 hrs

Cytotoxicity against human A549 cells assessed as growth inhibition after 24 hrs by MTT assay, IC50 = 1.9 μM.

24641975

DU145

Cytotoxicity assay

24 hrs

Cytotoxicity against human DU145 cells assessed as growth inhibition after 24 hrs by MTT assay, IC50 = 1.9 μM.

24641975

COLO205

Cytotoxicity assay

24 hrs

Cytotoxicity against human COLO205 cells assessed as inhibition of tumor growth after 24 hrs, IC50 = 3.39 μM.

24657568

RPMI8226

Antileukemic assay

24 hrs

Antileukemic activity against human RPMI8226 cells assessed as inhibition of tumor growth after 24 hrs, IC50 = 3.55 μM.

24657568

HCC2998

Cytotoxicity assay

24 hrs

Cytotoxicity against human HCC2998 cells assessed as inhibition of tumor growth after 24 hrs, IC50 = 5.75 μM.

24657568

HCT15

Cytotoxicity assay

24 hrs

Cytotoxicity against human HCT15 cells assessed as inhibition of tumor growth after 24 hrs, IC50 = 6.61 μM.

24657568

KM12

Cytotoxicity assay

24 hrs

Cytotoxicity against human KM12 cells assessed as inhibition of tumor growth after 24 hrs, IC50 = 7.94 μM.

24657568

SW620

Cytotoxicity assay

24 hrs

Cytotoxicity against human SW620 cells assessed as inhibition of tumor growth after 24 hrs, IC50 = 18.6 μM.

24657568

NCI60

Cytotoxicity assay

24 hrs

Cytotoxicity against human NCI60 cells assessed as inhibition of tumor growth after 24 hrs, IC50 = 29.5 μM.

24657568

E0771

Cytotoxicity assay

3 days

Cytotoxicity against mouse E0771 cells after 3 days by SRB assay, IC50 = 0.28 μM.

24704691

HT-29

Cytotoxicity assay

3 days

Cytotoxicity against human HT-29 cells after 3 days by SRB assay, IC50 = 2.58 μM.

24704691

MCF7

Cytotoxicity assay

3 days

Cytotoxicity against human MCF7 cells after 3 days by SRB assay, IC50 = 2.86 μM.

24704691

SW480

Cytotoxicity assay

3 days

Cytotoxicity against human SW480 cells after 3 days by SRB assay, IC50 = 3.69 μM.

24704691

RKO

Cytotoxicity assay

3 days

Cytotoxicity against human RKO cells after 3 days by SRB assay, IC50 = 4.39 μM.

24704691

MCF10A

Cytotoxicity assay

3 days

Cytotoxicity against human MCF10A cells after 3 days by SRB assay, IC50 = 8.06 μM.

24704691

CCD-18Co

Cytotoxicity assay

3 days

Cytotoxicity against human CCD-18Co cells after 3 days by SRB assay, IC50 = 9.26 μM.

24704691

T47D

Cytotoxicity assay

3 days

Cytotoxicity against human T47D cells after 3 days by SRB assay, IC50 = 10.56 μM.

24704691

MDA-MB-231

Cytotoxicity assay

3 days

Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay, IC50 = 18.12 μM.

24704691

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as growth inhibition measured at 48 hrs by SRB assay, IC50 = 0.98 μM.

24727462

HeLa

Cytotoxicity assay

2 days

Cytotoxicity against human HeLa cells after 2 days by MTT assay, IC50 = 7.34 μM.

24767839

MCF7

Cytotoxicity assay

2 days

Cytotoxicity against human MCF7 cells after 2 days by MTT assay, IC50 = 11.5 μM.

24767839

HT-29

Cytotoxicity assay

2 days

Cytotoxicity against human HT-29 cells after 2 days by MTT assay, IC50 = 17.2 μM.

24767839

A549

Cytotoxicity assay

2 days

Cytotoxicity against human A549 cells after 2 days by MTT assay, IC50 = 44.05 μM.

24767839

A549

Growth inhibition assay

48 hrs

Growth inhibition of human A549 cells after 48 hrs by SRB assay, GI50 = 4.55 μM.

24797798

PC3

Cytotoxicity assay

72 hrs

Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50 = 4.68 μM.

24798098

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.76 μM.

24798098

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 8.13 μM.

24798098

EC109

Cytotoxicity assay

72 hrs

Cytotoxicity against human EC109 cells after 72 hrs by MTT assay, IC50 = 24.14 μM.

24798098

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.08 μM.

24819956

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 10.54 μM.

24819956

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 11.12 μM.

24819956

A549

Cytotoxicity assay

24 hrs

Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50 = 1.3 μM.

24835633

HeLa

Cytotoxicity assay

24 hrs

Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 1.3 μM.

24835633

MCF7

Cytotoxicity assay

24 hrs

Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay, IC50 = 1.4 μM.

24835633

DU145

Cytotoxicity assay

24 hrs

Cytotoxicity against human DU145 cells after 24 hrs by MTT assay, IC50 = 1.5 μM.

24835633

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 3.52 μM.

24835817

EC9706

Antiproliferative assay

48 hrs

Antiproliferative activity against human EC9706 cells after 48 hrs by MTT assay, IC50 = 9.45 μM.

24835817

MGC803

Antiproliferative assay

48 hrs

Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 11.34 μM.

24835817

L1210

Cytostatic activity assay

48 hrs

Cytostatic activity against mouse L1210 cells assessed as inhibition of proliferation after 48 hrs by Coulter cell counting method, IC50 = 0.33 μM.

24906510

HeLa

Cytostatic activity assay

72 hrs

Cytostatic activity against human HeLa cells assessed as inhibition of proliferation after 72 hrs by Coulter cell counting method, IC50 = 0.54 μM.

24906510

CEM

Cytostatic activity assay

72 hrs

Cytostatic activity against human CEM cells assessed as inhibition of proliferation after 72 hrs by Coulter cell counting method, IC50 = 18 μM.

24906510

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 2.2 μM.

24910974

HCT15

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 4.5 μM.

24910974

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay, IC50 = 4.9 μM.

24910974

WM266.4

Antiproliferative assay

24 hrs

Antiproliferative activity against human WM266.4 cells after 24 hrs by MTT assay, GI50 = 28.76 μM.

24934992

HeLa

Antiproliferative assay

24 hrs

Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay, GI50 = 30.21 μM.

24934992

MDA-MB-231

Antiproliferative assay

48 hrs

Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 2.45 μM.

24941129

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.78 μM.

24941129

KCL22

Antiproliferative assay

48 hrs

Antiproliferative activity against human KCL22 cells after 48 hrs by MTT assay, IC50 = 3.52 μM.

24941129

Cytotoxicity assay

48 hrs

Cytotoxicity against human KB cells after 48 hrs by MTT assay, IC50 = 1.23 μM.

24953029

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 10.05 μM.

24953029

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 23.33 μM.

24953029

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 34.34 μM.

24953029

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 38.34 μM.

24953029

CNE

Cytotoxicity assay

48 hrs

Cytotoxicity against human CNE cells after 48 hrs by MTT assay, IC50 = 45.1 μM.

24953029

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 45.14 μM.

24953029

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 46.93 μM.

24953029

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay, IC50 = 4.21 μM.

24956552

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 12 μM.

24956552

A549

Cytotoxicity assay

24 to 48 hrs

Cytotoxicity against human A549 cells assessed as growth inhibition after 24 to 48 hrs by sulforhodamine B assay, IC50 = 1.65 μM.

24996138

MGC803

Anticancer assay

72 hrs

Anticancer activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 3.45 μM.

25001482

MCF7

Anticancer assay

72 hrs

Anticancer activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.12 μM.

25001482

EC9706

Anticancer assay

72 hrs

Anticancer activity against human EC9706 cells after 72 hrs by MTT assay, IC50 = 8.07 μM.

25001482

SSMC-7721

Anticancer assay

72 hrs

Anticancer activity against human SSMC-7721 cells after 72 hrs by MTT assay, IC50 = 15.08 μM.

25001482

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 24.6 μM.

25016234

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 35.41 μM.

25016234

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 39.88 μM.

25016234

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 46.83 μM.

25016234

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay, IC50 = 0.5 μM.

25066282

SW620

Cytotoxicity assay

72 hrs

Cytotoxicity against human SW620 cells after 72 hrs by MTS assay, IC50 = 5.3 μM.

25066282

MCF7

Anticancer assay

72 hrs

Anticancer activity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay, IC50 = 4.6 μM.

25086915

EC9706

Anticancer assay

72 hrs

Anticancer activity against human EC9706 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay, IC50 = 4.7 μM.

25086915

MGC803

Anticancer assay

72 hrs

Anticancer activity against human MGC803 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay, IC50 = 10 μM.

25086915

HeLa

Anticancer assay

72 hrs

Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay, IC50 = 12 μM.

25086915

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 7.62 μM.

25113877

MGC803

Antiproliferative assay

48 hrs

Antiproliferative activity against human MGC803 cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 7.76 μM.

25113877

CNE

Antiproliferative assay

48 hrs

Antiproliferative activity against human CNE cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 15.07 μM.

25113877

Bel7402

Antiproliferative assay

48 hrs

Antiproliferative activity against human Bel7402 cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 19.84 μM.

25113877

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 29.98 μM.

25151580

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 35.34 μM.

25151580

SMMC-7404

Cytotoxicity assay

48 hrs

Cytotoxicity against human SMMC-7404 cells after 48 hrs by MTT assay, IC50 = 40.21 μM.

25151580

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 44.04 μM.

25151580

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 46.93 μM.

25151580

B16

Antiproliferative assay

48 hrs

Antiproliferative activity against mouse B16 cells after 48 hrs by MTT assay, IC50 = 17.85 μM.

25164762

HL60

Antiproliferative assay

48 hrs

Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay, IC50 = 27.01 μM.

25164762

Hep

Cytotoxicity assay

48 hrs

Cytotoxicity against human Hep cells after 48 hrs by SRB assay, IC50 = 0.5 μM.

25176329

IMR32

Cytotoxicity assay

48 hrs

Cytotoxicity against human IMR32 cells after 48 hrs by SRB assay, IC50 = 1.3 μM.

25176329

B16F10

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse B16F10 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 0.87 μM.

25180925

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 7.69 μM.

25180925

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 8.93 μM.

25180925

EC109

Cytotoxicity assay

72 hrs

Cytotoxicity against human EC109 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 10.81 μM.

25180925

HEK293

Antiproliferative assay

24 hrs

Antiproliferative activity against HEK293 cells after 24 hrs by MTT assay, IC50 = 48.7 μM.

25198997

Bel7402

Cytotoxicity assay

96 hrs

Cytotoxicity against human Bel7402 cells assessed as growth inhibition rate after 96 hrs by MTT assay, IC50 = 2.23 μM.

25203783

HCT8

Cytotoxicity assay

96 hrs

Cytotoxicity against human HCT8 cells assessed as growth inhibition rate after 96 hrs by MTT assay, IC50 = 3.54 μM.

25203783

C33A

Cytotoxicity assay

96 hrs

Cytotoxicity against human C33A cells assessed as growth inhibition rate after 96 hrs by MTT assay, IC50 = 4.61 μM.

25203783

A549

Cytotoxicity assay

96 hrs

Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay, IC50 = 6.69 μM.

25203783

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 0.01 μM.

25259515

THP1

Cytotoxicity assay

48 hrs

Cytotoxicity against human THP1 cells after 48 hrs by SRB assay, IC50 = 0.04 μM.

25259515

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells after 48 hrs by trypan blue dye exclusion method, IC50 = 14.6 μM.

25261825

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells after 48 hrs by trypan blue dye exclusion method, IC50 = 15.3 μM.

25261825

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells after 48 hrs by LDH release assay, IC50 = 15.4 μM.

25261825

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells after 48 hrs by MTT method, IC50 = 15.6 μM.

25261825

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells after 48 hrs by MTT method, IC50 = 16.3 μM.

25261825

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells after 48 hrs by LDH release assay, IC50 = 16.8 μM.

25261825

L1210

Cytostatic activity assay

48 hrs

Cytostatic activity against mouse L1210 cells after 48 hrs by Coulter counting, IC50 = 0.33 μM.

25435471

HeLa

Cytostatic activity assay

72 hrs

Cytostatic activity against human HeLa cells after 72 hrs by Coulter counting, IC50 = 2.6 μM.

25435471

CEM

Cytostatic activity assay

72 hrs

Cytostatic activity against human CEM cells after 72 hrs by Coulter counting, IC50 = 18 μM.

25435471

LoVo

Antiproliferative assay

48 hrs

Antiproliferative activity against human LoVo cells assessed as cell-growth inhibition after 48 hrs by MTT assay, IC50 = 12.7 μM.

25453794

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells assessed as cell-growth inhibition after 48 hrs by MTT assay, IC50 = 16.3 μM.

25453794

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells assessed as cell-growth inhibition after 48 hrs by MTT assay, IC50 = 18.1 μM.

25453794

BGC823

Antiproliferative assay

48 hrs

Antiproliferative activity against human BGC823 cells assessed as cell-growth inhibition after 48 hrs by MTT assay, IC50 = 35.6 μM.

25453794

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells assessed as cell-growth inhibition after 48 hrs by MTT assay, IC50 = 36.2 μM.

25453794

U87

Antiproliferative assay

48 hrs

Antiproliferative activity against human U87 cells assessed as cell-growth inhibition after 48 hrs by MTT assay, IC50 = 38.2 μM.

25453794

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 30.45 μM.

25462253

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 36.04 μM.

25462253

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 36.53 μM.

25462253

MCF7

Anticancer assay

48 hrs

Anticancer activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 26.9 μM.

25462264

GES-1

Cytotoxicity assay

48 hrs

Cytotoxicity against human GES-1 cells after 48 hrs by MTT assay, IC50 = 30.9 μM.

25462264

K562

Anticancer assay

48 hrs

Anticancer activity against human K562 cells after 48 hrs by MTT assay, IC50 = 31.6 μM.

25462264

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay, IC50 = 6 μM.

25462277

T47D

Cytotoxicity assay

72 hrs

Cytotoxicity against human T47D cells after 72 hrs by SRB assay, IC50 = 7.9 μM.

25462277

HuH7

Cytotoxicity assay

72 hrs

Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay, IC50 = 30.7 μM.

25462277

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by WST-1 assay, IC50 = 34.48 μM.

25466196

SKBR3

Cytotoxicity assay

48 hrs

Cytotoxicity against human SKBR3 cells overexpressing HER2 assessed as cell growth inhibition after 48 hrs by WST-1 assay, IC50 = 38.88 μM.

25466196

B16

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse B16 cells assessed as cell survival after 48 hrs by MTT assay, IC50 = 7.64 μM.

25506718

MKN28

Cytotoxicity assay

48 hrs

Cytotoxicity against human MKN28 cells assessed as cell survival after 48 hrs by MTT assay, IC50 = 9.67 μM.

25506718

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells assessed as cell survival after 48 hrs by MTT assay, IC50 = 13.45 μM.

25506718

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 9.09 μM.

25529742

SF763

Antiproliferative assay

72 hrs

Antiproliferative activity against human SF763 cells after 72 hrs by MTT assay, IC50 = 9.34 μM.

25529742

HL60

Antiproliferative assay

72 hrs

Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay, IC50 = 10.45 μM.

25529742

B16

Antiproliferative assay

72 hrs

Antiproliferative activity against mouse B16 cells after 72 hrs by MTT assay, IC50 = 10.52 μM.

25529742

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 11.78 μM.

25529742

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 3.71 μM.

25554922

Bcap37

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay, IC50 = 5.18 μM.

25554922

SGC7901

Cytotoxicity assay

48 hrs

Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 6.56 μM.

25554922

BALB/3T3

Antiproliferative assay

72 hrs

Antiproliferative activity against mouse BALB/3T3 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 3.23 μM.

25644674

LoVo

Antiproliferative assay

72 hrs

Antiproliferative activity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 4.69 μM.

25644674

doxorubicin-resistant LoVo/DX

Antiproliferative assay

72 hrs

Antiproliferative activity against human doxorubicin-resistant LoVo/DX cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 6 μM.

25644674

SW707

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW707 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 20.46 μM.

25644674

vincristine-resistant HL60/Vinc

Antiproliferative assay

72 hrs

Antiproliferative activity against human vincristine-resistant HL60/Vinc cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 21.15 μM.

25644674

HL60

Antiproliferative assay

72 hrs

Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 22.54 μM.

25644674

HT-29

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 25.08 μM.

25644674

LS180

Antiproliferative assay

72 hrs

Antiproliferative activity against human LS180 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 38.92 μM.

25644674

B16F10

Anticancer assay

72 hrs

Anticancer activity against mouse B16F10 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 1.43 μM.

25655718

MGC803

Anticancer assay

72 hrs

Anticancer activity against human MGC803 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 8.43 μM.

25655718

MCF7

Anticancer assay

72 hrs

Anticancer activity against human MCF7 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 9.12 μM.

25655718

EC109

Anticancer assay

72 hrs

Anticancer activity against human EC109 cells assessed as inhibition of proliferation after 72 hrs by MTT assay, IC50 = 11.61 μM.

25655718

HCT8

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT8 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay, IC50 = 0.91 μM.

25675144

HCT8

Antiproliferative assay

72 hrs

Antiproliferative activity against 5-FU resistant human HCT8 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay, IC50 = 36.638 μM.

25675144

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 10.72 μM.

25707012

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 12.24 μM.

25707012

EC9706

Cytotoxicity assay

72 hrs

Cytotoxicity against human EC9706 cells after 72 hrs by MTT assay, IC50 = 15.67 μM.

25707012

SMMC7721

Cytotoxicity assay

72 hrs

Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 20.4 μM.

25707012

SW1573

Antiproliferative assay

48 hrs

Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay, GI50 = 4.3 μM.

25752525

HBL100

Antiproliferative assay

48 hrs

Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay, GI50 = 5.5 μM.

25752525

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay, GI50 = 15 μM.

25752525

T47D

Antiproliferative assay

48 hrs

Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay, GI50 = 47 μM.

25752525

WiDr

Antiproliferative assay

48 hrs

Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay, GI50 = 49 μM.

25752525

MGC803

Anticancer assay

48 hrs

Anticancer activity against human MGC803 cells assessed as cell survival after 48 hrs by MTT assay, IC50 = 3.58 μM.

25812966

SMMC7721

Anticancer assay

48 hrs

Anticancer activity against human SMMC7721 cells assessed as cell survival after 48 hrs by MTT assay, IC50 = 4.87 μM.

25812966

HepG2

Anticancer assay

48 hrs

Anticancer activity against human HepG2 cells assessed as cell survival after 48 hrs by MTT assay, IC50 = 5.86 μM.

25812966

SGC7901

Anticancer assay

48 hrs

Anticancer activity against human SGC7901 cells assessed as cell survival after 48 hrs by MTT assay, IC50 = 6.12 μM.

25812966

SKOV3

Cytotoxicity assay

2 days

Cytotoxicity against human SKOV3 cells after 2 days by MTT assay, IC50 = 27.34 μM.

25841196

HepG2

Cytotoxicity assay

2 days

Cytotoxicity against human HepG2 cells after 2 days by MTT assay, IC50 = 31.98 μM.

25841196

A549

Cytotoxicity assay

2 days

Cytotoxicity against human A549 cells after 2 days by MTT assay, IC50 = 38.23 μM.

25841196

T24

Cytotoxicity assay

2 days

Cytotoxicity against human T24 cells after 2 days by MTT assay, IC50 = 40.57 μM.

25841196

SPCA2

Cytotoxicity assay

2 days

Cytotoxicity against human SPCA2 cells after 2 days by MTT assay, IC50 = 44.1 μM.

25841196

NCI-H460

Cytotoxicity assay

2 days

Cytotoxicity against human NCI-H460 cells after 2 days by MTT assay, IC50 = 46.15 μM.

25841196

MGC803

Cytotoxicity assay

2 days

Cytotoxicity against human MGC803 cells after 2 days by MTT assay, IC50 = 47.39 μM.

25841196

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 29.58 μM.

25841199

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 30.79 μM.

25841199

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 36.34 μM.

25841199

T24

Cytotoxicity assay

48 hrs

Cytotoxicity against human T24 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 37.56 μM.

25841199

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells assessed as cell viability after 48 hrs by MTT assay, IC50 = 40.94 μM.

25841199

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 5.82 μM.

25870131

DU145

Cytotoxicity assay

48 hrs

Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 6.37 μM.

25870131

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 7.51 μM.

25870131

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by WST8 assay, IC50 = 2.8 μM.

25919052

PANC1

Antiproliferative assay

72 hrs

Antiproliferative activity against human PANC1 cells after 72 hrs by WST8 assay, IC50 = 3.7 μM.

25919052

PSN1

Antiproliferative assay

72 hrs

Antiproliferative activity against human PSN1 cells after 72 hrs by WST8 assay, IC50 = 4.4 μM.

25919052

MDA-MB-231

Antiproliferative assay

72 hrs

Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by WST8 assay, IC50 = 5.2 μM.

25919052

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by WST8 assay, IC50 = 5.8 μM.

25919052

TIG3

Antiproliferative assay

72 hrs

Antiproliferative activity against human TIG3 cells after 72 hrs by WST8 assay, IC50 = 8.4 μM.

25919052

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay, IC50 = 8.93 μM.

25959813

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay, IC50 = 9.56 μM.

25959813

Bel7402

Antiproliferative assay

48 hrs

Antiproliferative activity against human Bel7402 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay, IC50 = 19.91 μM.

25959813

NIH/3T3

Antiproliferative assay

48 hrs

Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay, IC50 = 22.36 μM.

25959813

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay, IC50 = 40.38 μM.

25959813

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 8 μM.

25969171

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by sulphorhodamine B assay, IC50 = 2.2 μM.

26222449

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by sulphorhodamine B assay, IC50 = 4.5 μM.

26222449

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by sulphorhodamine B assay, IC50 = 4.9 μM.

26222449

HCT8

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay, IC50 = 6.3 μM.

26227777

Bel7402

Cytotoxicity assay

72 hrs

Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 10.07 μM.

26227777

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 14.15 μM.

26227777

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 16.42 μM.

26227777

A549

Anticancer assay

48 hrs

Anticancer activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay, IC50 = 2.13 μM.

26231080

MCF7

Anticancer assay

48 hrs

Anticancer activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay, IC50 = 2.36 μM.

26231080

HeLa

Anticancer assay

48 hrs

Anticancer activity against human HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay, IC50 = 4.6 μM.

26231080

HaCaT

Cytotoxicity assay

48 hrs

Cytotoxic activity against human HaCaT cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay, IC50 = 15.26 μM.

26231080

Hep3B

Cytotoxicity assay

2 days

Cytotoxicity against human Hep3B cells assessed as induction of cell death incubated for 2 days by MTT assay, IC50 = 1.5 μM.

26259802

Bcap37

Cytotoxicity assay

2 days

Cytotoxicity against human Bcap37 cells assessed as induction of cell death incubated for 2 days by MTT assay, IC50 = 5.58 μM.

26259802

MCF7

Cytotoxicity assay

2 days

Cytotoxicity against human MCF7 cells assessed as induction of cell death incubated for 2 days by MTT assay, IC50 = 11.5 μM.

26259802

HepG2

Cytotoxicity assay

2 days

Cytotoxicity against human HepG2 cells assessed as induction of cell death incubated for 2 days by MTT assay, IC50 = 40.34 μM.

26259802

A549

Cytotoxicity assay

2 days

Cytotoxicity against human A549 cells assessed as induction of cell death incubated for 2 days by MTT assay, IC50 = 44.05 μM.

26259802

SW620

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay, IC50 = 0.79 μM.

26291038

MIAPaCa2

Antiproliferative assay

72 hrs

Antiproliferative activity against human MIAPaCa2 cells incubated for 72 hrs by MTT assay, IC50 = 11.67 μM.

26291038

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 5.012 μM.

26301558

DU145

Antiproliferative assay

48 hrs

Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 6.072 μM.

26301558

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 7.244 μM.

26301558

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 8.317 μM.

26301558

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 19.39 μM.

26363869

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 22.28 μM.

26363869

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50 = 22.63 μM.

26363869

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 46.83 μM.

26363869

HT-29

Cytotoxicity assay

48 hrs

Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by WST-1 assay, IC50 = 15.83 μM.

26413725

PA1

Anticancer assay

48 hrs

Anticancer activity against human PA1 cells after 48 hrs by MTT assay, IC50 = 7.59 μM.

26413726

BT549

Anticancer assay

48 hrs

Anticancer activity against human BT549 cells after 48 hrs by MTT assay, IC50 = 19.82 μM.

26413726

DU145

Anticancer assay

48 hrs

Anticancer activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 39.17 μM.

26413726

MDA-MB-231

Anticancer assay

48 hrs

Anticancer activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 45.43 μM.

26413726

SH-SY5Y

Antiproliferative assay

72 hrs

Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT-based Mosmann assay relative to control, GI50 = 1.5 μM.

26539626

Caco2

Antiproliferative assay

72 hrs

Antiproliferative activity against human Caco2 cells after 72 hrs by MTT-based Mosmann assay relative to control, GI50 = 2.2 μM.

26539626

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 6.76 μM.

26595184

SGC7901

Antiproliferative assay

72 hrs

Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 11.9 μM.

26595184

MDA-MB-435S

Antiproliferative assay

72 hrs

Antiproliferative activity against human MDA-MB-435S cells after 72 hrs by MTT assay, IC50 = 15.19 μM.

26595184

L02

Cytotoxicity assay

72 hrs

Cytotoxicity against human L02 cells after 72 hrs by MTT assay, IC50 = 25.9 μM.

26595184

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 42.5 μM.

26595184

PANC1

Antiproliferative assay

72 hrs

Antiproliferative activity against human PANC1 cells after 72 hrs by WST-8 assay, IC50 = 0.4 μM.

26606140

MDA-MB-231

Antiproliferative assay

72 hrs

Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by WST-8 assay, IC50 = 1.1 μM.

26606140

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by WST-8 assay, IC50 = 6.4 μM.

26606140

PSN1

Antiproliferative assay

72 hrs

Antiproliferative activity against human PSN1 cells after 72 hrs by WST-8 assay, IC50 = 8.7 μM.

26606140

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by WST-8 assay, IC50 = 9 μM.

26606140

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 0.09 μM.

26617970

SW620

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 0.79 μM.

26617970

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTS assay, IC50 = 3.52 μM.

26703795

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay, IC50 = 5.53 μM.

26703795

HT-29

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay, IC50 = 24.5 μM.

26703795

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay, IC50 = 32.18 μM.

26703795

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay, IC50 = 43.71 μM.

26703795

SKOV3

Cytotoxicity assay

48 hrs

Cytotoxic activity against human SKOV3 cells assessed as inhibition of cell growth after 48 hrs by MTT assay, IC50 = 22.43 μM.

26706349

HCT116

Cytotoxicity assay

48 hrs

Cytotoxic activity against human HCT116 cells assessed as inhibition of cell growth after 48 hrs by MTT assay, IC50 = 24.58 μM.

26706349

Bel7404

Cytotoxicity assay

48 hrs

Cytotoxic activity against human Bel7404 cells assessed as inhibition of cell growth after 48 hrs by MTT assay, IC50 = 30.23 μM.

26706349

A549

Cytotoxicity assay

48 hrs

Cytotoxic activity against human A549 cells assessed as inhibition of cell growth after 48 hrs by MTT assay, IC50 = 31.33 μM.

26706349

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxic activity against human NCI-H460 cells assessed as inhibition of cell growth after 48 hrs by MTT assay, IC50 = 35.52 μM.

26706349

MDST8

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDST8 cells after 72 hrs by CCK8 assay, IC50 = 0.064 μM.

26725029

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay, IC50 = 0.52 μM.

26725029

KM12

Cytotoxicity assay

48 hrs

Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay, IC50 = 14.8 μM.

26727215

HT-29

Cytotoxicity assay

48 hrs

Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay, IC50 = 14.8 μM.

26727215

HCC2998

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay, IC50 = 14.8 μM.

26727215

COLO205

Cytotoxicity assay

48 hrs

Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay, IC50 = 14.8 μM.

26727215

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B assay, IC50 = 14.8 μM.

26727215

HCT15

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 14.8 μM.

26727215

SW620

Cytotoxicity assay

48 hrs

Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay, IC50 = 14.8 μM.

26727215

MCF7

Antiproliferative assay

96 hrs

Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay, IC50 = 0.9 μM.

26731300

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay, IC50 = 4.9 μM.

26731300

HT-29

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay, IC50 = 5.3 μM.

26731300

T84

Antiproliferative assay

96 hrs

Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay, IC50 = 6.2 μM.

26731300

PC3

Cytotoxicity assay

72 hrs

Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 1.44 μM.

26735909

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 3.47 μM.

26735909

U87MG

Cytotoxicity assay

72 hrs

Cytotoxicity against human U87MG cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 3.61 μM.

26735909

L929

Antiproliferative assay

48 hrs

Antiproliferative activity against mouse L929 cells after 48 hrs by CCK8 assay, IC50 = 2.98 μM.

26786698

SMMC7721

Antiproliferative assay

48 hrs

Antiproliferative activity against human SMMC7721 cells after 48 hrs by CCK8 assay, IC50 = 5.62 μM.

26786698

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by CCK8 assay, IC50 = 8.13 μM.

26786698

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay, IC50 = 17.21 μM.

26786698

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 1.4 μM.

26854375

THP1

Cytotoxicity assay

48 hrs

Cytotoxicity against human THP1 cells after 48 hrs by MTT assay, IC50 = 1.7 μM.

26854375

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 2 μM.

26854375

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 2.3 μM.

26854375

HCT8

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 32.31 μM.

26873416

WI38

Cytotoxicity assay

48 hrs

Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 38.91 μM.

26873416

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 41.62 μM.

26873416

Hep3B

Cytotoxicity assay

48 hrs

Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay, IC50 = 10.53 μM.

26883148

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 34.27 μM.

26883148

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 42.78 μM.

26883148

Bcap37

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay, IC50 = 47.09 μM.

26883148

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 49.72 μM.

26883148

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 26.14 μM.

26922223

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 26.18 μM.

26922223

HL60

Antiproliferative assay

72 hrs

Antiproliferative activity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 27.43 μM.

26922223

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 38.3 μM.

26922223

HepG2

Antiproliferative assay

72 hrs

Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 49.02 μM.

26922223

HT-29

Anticancer assay

72 hrs

Anticancer activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTT assay, IC50 = 6.3 μM.

26922233

RKO

Anticancer assay

72 hrs

Anticancer activity against human RKO cells assessed as inhibition of cell growth after 72 hrs by MTT assay, IC50 = 6.8 μM.

26922233

HT-29

Anticancer assay

48 hrs

Anticancer activity against human HT-29 cells assessed as inhibition of cell growth after 48 hrs by MTT assay, IC50 = 25 μM.

26922233

HCT116

Anticancer assay

72 hrs

Anticancer activity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTT assay, IC50 = 27.8 μM.

26922233

RKO

Anticancer assay

48 hrs

Anticancer activity against human RKO cells assessed as inhibition of cell growth after 48 hrs by MTT assay, IC50 = 41.1 μM.

26922233

Cytotoxicity assay

72 hrs

Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50 = 4.84 μM.

27073055

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by SRB assay, IC50 = 6.23 μM.

27073055

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7cells after 72 hrs by SRB assay, IC50 = 6.53 μM.

27073055

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay, IC50 = 6.6 μM.

27073055

HDF

Cytotoxicity assay

72 hrs

Cytotoxicity against HDF cells after 72 hrs by SRB assay, IC50 = 7.02 μM.

27073055

143B

Cytotoxicity assay

72 hrs

Cytotoxicity against human 143B cells after 72 hrs by SRB assay, IC50 = 13.01 μM.

27073055

thymidine kinase deficient 143B

Cytotoxicity assay

72 hrs

Cytotoxicity against human thymidine kinase deficient 143B cells after 72 hrs by SRB assay, IC50 = 16.31 μM.

27073055

U87MG

Cytotoxicity assay

72 hrs

Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 72 hrs by Z2 coulter counter method, IC50 = 18.25 μM.

27081742

PC3

Antiproliferative assay

48 hrs

Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, IC50 = 2.76 μM.

27092413

HT-29

Antiproliferative assay

48 hrs

Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 2.8 μM.

27092413

U87MG

Antiproliferative assay

48 hrs

Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay, IC50 = 3.65 μM.

27092413

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 3.98 μM.

27092413

HaCaT

Antiproliferative assay

48 hrs

Antiproliferative activity against human HaCaT cells after 48 hrs by MTT assay, IC50 = 16.15 μM.

27092413

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 1.25 μM.

27105028

EC109

Antiproliferative assay

72 hrs

Antiproliferative activity against human EC109 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 3.17 μM.

27105028

SH-SY5Y

Antiproliferative assay

72 hrs

Antiproliferative activity against human SH-SY5Y cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 3.26 μM.

27105028

U87

Antiproliferative assay

72 hrs

Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 5.61 μM.

27105028

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 7.61 μM.

27105028

MDA-MB-231

Antiproliferative assay

48 hrs

Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 24.6 μM.

27128180

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 30.41 μM.

27128180

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 35.41 μM.

27128180

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 46.83 μM.

27128180

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 13.5 μM.

27133593

Bcap37

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay, IC50 = 15.47 μM.

27133593

Hep3B

Cytotoxicity assay

48 hrs

Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay, IC50 = 17.53 μM.

27133593

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 21.58 μM.

27133593

U251

Cytotoxicity assay

48 hrs

Cytotoxicity against human U251 cells after 48 hrs by MTT assay, IC50 = 24.69 μM.

27133593

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 25.17 μM.

27133593

LNCAP

Cytotoxicity assay

24 hrs

Cytotoxicity against human LNCAP cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay, IC50 = 0.03 μM.

27156770

PC3

Cytotoxicity assay

24 hrs

Cytotoxicity against human PC3 cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay, IC50 = 0.03 μM.

27156770

Bcap37

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bcap37 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 5.18 μM.

27189676

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 11.5 μM.

27189676

Hep3B

Cytotoxicity assay

48 hrs

Cytotoxicity against human Hep3B cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 22.99 μM.

27189676

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 40.34 μM.

27189676

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 44.05 μM.

27189676

PA1

Cytotoxicity assay

48 hrs

Cytotoxicity against human PA1 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 8.51 μM.

27210438

U87MG

Cytotoxicity assay

48 hrs

Cytotoxicity against human U87MG cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 15.48 μM.

27210438

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 32.27 μM.

27210438

LNCAP

Cytotoxicity assay

48 hrs

Cytotoxicity against human LNCAP cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 47.18 μM.

27210438

MCF7

Cytotoxicity assay

24 hrs

Cytotoxicity against human MCF7 cells assessed as cell survivability after 24 hrs by crystal violet staining based microscopic analysis, IC50 = 11.1 μM.

27234893

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay, IC50 = 46.83 μM.

27287368

A375-S2

Antiproliferative assay

48 hrs

Antiproliferative activity against human A375-S2 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay, IC50 = 1.91 μM.

27295506

ACHN

Antiproliferative assay

48 hrs

Antiproliferative activity against human ACHN cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay, IC50 = 2.73 μM.

27295506

22Rv1

Antiproliferative assay

48 hrs

Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay, IC50 = 3.83 μM.

27295506

C4-2B

Antiproliferative assay

48 hrs

Antiproliferative activity against human C4-2B cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay, IC50 = 5.64 μM.

27295506

A498

Antiproliferative assay

48 hrs

Antiproliferative activity against human A498 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay, IC50 = 8.83 μM.

27295506

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay, IC50 = 2.8 μM.

27311895

MDA-MB-231

Antiproliferative assay

72 hrs

Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay, IC50 = 5.2 μM.

27311895

HeLa

Antiproliferative assay

72 hrs

Antiproliferation activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by WST-8 assay, IC50 = 5.8 μM.

27311895

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 3 μM.

27343853

WI38

Cytotoxicity assay

48 hrs

Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 4 μM.

27343853

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 8 μM.

27343853

UO31

Cytotoxicity assay

48 hrs

Cytotoxicity against human UO31 cells measured after 48 hrs by SRB assay, GI50 = 6.76083 μM.

27391135

U251

Cytotoxicity assay

48 hrs

Cytotoxicity against human U251 cells measured after 48 hrs by SRB assay, GI50 = 42.6579 μM.

27391135

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 15.38 μM.

27448774

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 35.91 μM.

27448774

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 39.86 μM.

27448774

Caco2

Growth inhibition assay

72 hrs

Growth inhibition of human Caco2 cells measured after 72 hrs by MTT assay, GI50 = 3.3 μM.

27504537

MCF7

Growth inhibition assay

72 hrs

Growth inhibition of human MCF7 cells measured after 72 hrs by MTT assay, GI50 = 3.6 μM.

27504537

PC3

Growth inhibition assay

72 hrs

Growth inhibition of human PC3 cells measured after 72 hrs by MTT assay, GI50 = 4.1 μM.

27504537

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay, IC50 = 6.8 μM.

27537924

SGC7901

Cytotoxicity assay

72 hrs

Cytotoxicity against human SGC7901 cells measured after 72 hrs by MTT assay, IC50 = 11.9 μM.

27537924

MDA-MB-435S

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDA-MB-435S cells measured after 72 hrs by MTT assay, IC50 = 15.2 μM.

27537924

PC3

Cytotoxicity assay

72 hrs

Cytotoxicity against human PC3 cells measured after 72 hrs by MTT assay, IC50 = 42.5 μM.

27537924

colon cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human colon cancer cells after 48 hrs by SRB assay, GI50 = 8.4 μM.

27554444

leukemia cell

Growth inhibition assay

48 hrs

Growth inhibition of human leukemia cells after 48 hrs by SRB assay, GI50 = 15.1 μM.

27554444

prostate cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human prostate cancer cells after 48 hrs by SRB assay, GI50 = 22.7 μM.

27554444

renal cancer cell

Growth inhibition assay

48 hrs

Growth inhibition of human renal cancer cells after 48 hrs by SRB assay, GI50 = 45.6 μM.

27554444

DU145

Cytotoxicity assay

48 hrs

Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 26.1 μM.

27561718

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 28.2 μM.

27561718

IOSE-144

Cytotoxicity assay

48 hrs

Cytotoxicity against human IOSE-144 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 36.1 μM.

27561718

SW780

Cytotoxicity assay

72 hrs

Cytotoxicity against human SW780 cells assessed as growth inhibition after 72 hrs by CCK8 assay, IC50 = 6.99 μM.

27597411

MGC803

Cytotoxicity assay

72 hrs

Cytotoxicity against human MGC803 cells assessed as growth inhibition after 72 hrs by CCK8 assay, IC50 = 10.64 μM.

27597411

HL-7702

Cytotoxicity assay

72 hrs

Cytotoxicity against human HL-7702 cells assessed as growth inhibition after 72 hrs by CCK8 assay, IC50 = 12.85 μM.

27597411

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by CCK8 assay, IC50 = 13.19 μM.

27597411

GES-1

Cytotoxicity assay

72 hrs

Cytotoxicity against human GES-1 cells assessed as growth inhibition after 72 hrs by CCK8 assay, IC50 = 13.75 μM.

27597411

TE1

Cytotoxicity assay

72 hrs

Cytotoxicity against human TE1 cells assessed as growth inhibition after 72 hrs by CCK8 assay, IC50 = 17.32 μM.

27597411

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 30.47 μM.

27614408

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 35.98 μM.

27614408

DU145

Cytotoxicity assay

48 hrs

Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 40.58 μM.

27614408

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 45.32 μM.

27614408

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition measured after 48 hrs by MTT assay, GI50 = 4.5 μM.

27688184

HepG2

Function assay

48 hrs

Hepatotoxicity against human HepG2 cells assessed as growth inhibition measured after 48 hrs by MTT assay, GI50 = 7 μM.

27688184

U87

Function assay

48 hrs

Neurotoxicity against human U87 cells assessed as growth inhibition measured after 48 hrs by MTT assay, GI50 = 13 μM.

27688184

HCT116

Growth inhibition assay

72 hrs

Growth inhibition of human HCT116 cells after 72 hrs by MTS assay, IC50 = 2.5 μM.

27704811

L1210

Antiproliferative assay

48 hrs

Anti-proliferative activity against mouse L1210 cells measured after 48 hrs by coulter counter method, IC50 = 0.33 μM.

27750154

HeLa

Antiproliferative assay

4 days

Anti-proliferative activity against human HeLa cells measured after 4 days by coulter counter method, IC50 = 0.54 μM.

27750154

CEM

Antiproliferative assay

72 hrs

Anti-proliferative activity against human CEM cells measured after 72 hrs by coulter counter method, IC50 = 18 μM.

27750154

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 7.35 μM.

27771599

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 9.25 μM.

27771599

EC109

Antiproliferative assay

72 hrs

Antiproliferative activity against human EC109 cells after 72 hrs by MTT assay, IC50 = 10.59 μM.

27771599

HUCCA

Cytotoxicity assay

24 hrs

Cytotoxicity against HUCCA cells assessed as decrease in cell viability after 24 hrs by MTT assay, IC50 = 13.4 μM.

27825763

QBC939

Cytotoxicity assay

24 hrs

Cytotoxicity against human QBC939 cells assessed as decrease in cell viability after 24 hrs by MTT assay, IC50 = 16.1 μM.

27825763

SW620

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 0.08 μM.

27875779

CFPAC-1

Antiproliferative assay

72 hrs

Antiproliferative activity against human CFPAC-1 cells after 72 hrs by MTT assay, IC50 = 0.14 μM.

27875779

WI38

Antiproliferative assay

72 hrs

Antiproliferative activity against human WI38 cells after 72 hrs by MTT assay, IC50 = 0.94 μM.

27875779

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 2.8 μM.

27875779

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 8.81 μM.

27875779

HepG2

Antiproliferative assay

72 hrs

Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 8.9 μM.

27875779

WISH

Cytotoxicity assay

24 hrs

Cytotoxicity against human WISH cells assessed as reduction in cell viability after 24 hrs by MTT assay, IC50 = 7.1 μM.

27951487

WI38

Cytotoxicity assay

24 hrs

Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 24 hrs by MTT assay, IC50 = 9.3 μM.

27951487

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 1.16 μM.

27987485

MDA-MB-231

Antiproliferative assay

72 hrs

Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 5 μM.

27987485

HepG2

Antiproliferative assay

72 hrs

Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 5 μM.

27987485

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.12 μM.

27987485

Hep3B

Cytotoxicity assay

48 hrs

Cytotoxic activity against human Hep3B cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 10.53 μM.

27993516

HepG2

Cytotoxicity assay

48 hrs

Cytotoxic activity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 32.6 μM.

27993516

HepG2

Growth inhibition assay

24 hrs

Growth inhibition of human HepG2 cells after 24 hrs by MTT assay, IC50 = 32.87 μM.

28011220

PA1

Growth inhibition assay

24 hrs

Growth inhibition of human PA1 cells after 24 hrs by MTT assay, IC50 = 39.5 μM.

28011220

HCT15

Growth inhibition assay

24 hrs

Growth inhibition of human HCT15 cells after 24 hrs by MTT assay, IC50 = 45.01 μM.

28011220

PC3

Cytotoxicity assay

72 hrs

Cytotoxic activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by SRB assay, IC50 = 15.31 μM.

28011223

SKOV3

Cytotoxicity assay

72 hrs

Cytotoxic activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by SRB assay, IC50 = 23.11 μM.

28011223

A549

Cytotoxicity assay

72 hrs

Cytotoxic activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay, IC50 = 32.15 μM.

28011223

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as decrease in cell proliferation after 48 hrs by MTT colorimetric assay, IC50 = 10.17 μM.

28038327

Hep3B

Cytotoxicity assay

48 hrs

Cytotoxicity against human Hep3B cells assessed as decrease in cell proliferation after 48 hrs by MTT colorimetric assay, IC50 = 10.53 μM.

28038327

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as decrease in cell proliferation after 48 hrs by MTT colorimetric assay, IC50 = 34.27 μM.

28038327

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as decrease in cell proliferation after 48 hrs by MTT colorimetric assay, IC50 = 42.78 μM.

28038327

Bcap37

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bcap37 cells assessed as decrease in cell proliferation after 48 hrs by MTT colorimetric assay, IC50 = 47.1 μM.

28038327

U251

Cytotoxicity assay

48 hrs

Cytotoxicity against human U251 cells assessed as decrease in cell proliferation after 48 hrs by MTT colorimetric assay, IC50 = 48.68 μM.

28038327

MGC803

Cytotoxicity assay

48 hrs

Cytotoxicity against human MGC803 cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 7.21 μM.

28038329

EC109

Cytotoxicity assay

48 hrs

Cytotoxicity against human EC109 cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 10.3 μM.

28038329

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay, IC50 = 29.31 μM.

28038329

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 10.5 μM.

28073676

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 19.2 μM.

28073676

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 29.2 μM.

28073676

BGC823

Antiproliferative assay

48 hrs

Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay, IC50 = 34.8 μM.

28073676

IOSE-144

Antiproliferative assay

48 hrs

Antiproliferative activity against human IOSE-144 cells after 48 hrs by MTT assay, IC50 = 38.1 μM.

28073676

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 26.14 μM.

28110871

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 38.3 μM.

28110871

PANC1

Antiproliferative assay

48 hrs

Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay, IC50 = 47.83 μM.

28110871

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 49.02 μM.

28110871

BCG823

Cytotoxicity assay

48 hrs

Cytotoxicity against human BCG823 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 10.1 μM.

28117202

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 16.1 μM.

28117202

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 17.2 μM.

28117202

EC9706

Antiproliferative assay

48 hrs

Antiproliferative activity against human EC9706 cells after 48 hrs by MTT assay, IC50 = 23.26 μM.

28119200

ECA109

Antiproliferative assay

48 hrs

Antiproliferative activity against human ECA109 cells after 48 hrs by MTT assay, IC50 = 30.25 μM.

28119200

K562

Growth inhibition assay

48 hrs

Growth inhibition of human K562 cells after 48 hrs by WST1 assay, IC50 = 38.58 μM.

28126436

KKU-M214

Cytotoxicity assay

72 hrs

Cytotoxicity against human KKU-M214 cells assessed as reduction in cell viability after 72 hrs by SRB assay, IC50 = 3.76 μM.

28140592

HL60

Antiproliferative assay

48 hrs

Antiproliferative activity against human HL60 cells after 48 hrs by MTS assay, IC50 = 1.62 μM.

28152430

NCI-H1299

Antiproliferative assay

48 hrs

Antiproliferative activity against human NCI-H1299 cells after 48 hrs by MTS assay, IC50 = 8.91 μM.

28152430

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 1.75 μM.

28165738

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 2.25 μM.

28165738

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 3.12 μM.

28165738

K562

Antiproliferative assay

72 hrs

Antiproliferative activity against human K562 cells after 72 hrs by MTT assay, IC50 = 3.54 μM.

28165738

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 10.53 μM.

28174107

Hep3B

Cytotoxicity assay

48 hrs

Cytotoxicity against human Hep3B cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 49.72 μM.

28174107

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 1.4 μM.

28219046

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 18.4 μM.

28219046

HuH7

Cytotoxicity assay

72 hrs

Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 21 μM.

28219046

A549

Cytotoxicity assay

24 hrs

Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50 = 1.2 μM.

28254697

HeLa

Cytotoxicity assay

24 hrs

Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 1.4 μM.

28254697

HepG2

Cytotoxicity assay

24 hrs

Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50 = 1.4 μM.

28254697

COLO205

Cytotoxicity assay

24 hrs

Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay, IC50 = 1.9 μM.

28254697

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay, IC50 = 5.94 μM.

28301815

LO2

Antiproliferative assay

72 hrs

Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay, IC50 = 32.546 μM.

28301815

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 9.02 μM.

28363444

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 13.31 μM.

28363444

BGC823

Antiproliferative assay

48 hrs

Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay, IC50 = 17.37 μM.

28363444

SW1116

Antiproliferative assay

48 hrs

Antiproliferative activity against human SW1116 cells after 48 hrs by MTT assay, IC50 = 18.52 μM.

28363444

MCF7

Antiproliferative assay

48 to 72 hrs

Antiproliferative activity against human MCF7 cells incubated for 48 to 72 hrs by MTT assay, IC50 = 7.67 μM.

28395218

A549

Antiproliferative assay

48 to 72 hrs

Antiproliferative activity against human A549 cells incubated for 48 to 72 hrs by MTT assay, IC50 = 10.65 μM.

28395218

SGC7901

Antiproliferative assay

48 to 72 hrs

Antiproliferative activity against human SGC7901 cells incubated for 48 to 72 hrs by MTT assay, IC50 = 13.25 μM.

28395218

HepG2

Antiproliferative assay

48 to 72 hrs

Antiproliferative activity against human HepG2 cells incubated for 48 to 72 hrs by MTT assay, IC50 = 17.44 μM.

28395218

PC3

Antiproliferative assay

48 to 72 hrs

Antiproliferative activity against human PC3 cells incubated for 48 to 72 hrs by MTT assay, IC50 = 38.61 μM.

28395218

MCF7

Growth inhibition assay

48 hrs

Growth inhibition of human MCF7 cells after 48 hrs by SRB assay, GI50 = 1.67 μM.

28400235

A549

Growth inhibition assay

48 hrs

Growth inhibition of human A549 cells after 48 hrs by SRB assay, GI50 = 2.09 μM.

28400235

DU145

Growth inhibition assay

48 hrs

Growth inhibition of human DU145 cells after 48 hrs by SRB assay, GI50 = 5.82 μM.

28400235

T47D

Antiproliferative assay

48 hrs

Antiproliferative activity against human T47D cells after 48 hrs by MTT assay, IC50 = 12.1 μM.

28400238

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 15.1 μM.

28400238

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 20.1 μM.

28400238

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 26.2 μM.

28400238

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50 = 1.2 μM.

28431881

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 1.6 μM.

28431881

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 1.86 μM.

28431881

DU145

Cytotoxicity assay

48 hrs

Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 2.18 μM.

28431881

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 4.33 μM.

28431881

HGC27

Cytotoxicity assay

48 hrs

Cytotoxicity against human HGC27 cells after 48 hrs by MTT assay, IC50 = 14.72 μM.

28431881

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 6.56 μM.

28456031

HGC27

Antiproliferative assay

72 hrs

Antiproliferative activity against human HGC27 cells after 72 hrs by MTT assay, IC50 = 8.22 μM.

28456031

NCI-H1650

Antiproliferative assay

72 hrs

Antiproliferative activity against human NCI-H1650 cells after 72 hrs by MTT assay, IC50 = 12.52 μM.

28456031

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 4.16 μM.

28458133

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 24.33 μM.

28458133

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 28.73 μM.

28458133

HepG2

Antiproliferative assay

72 hrs

Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 29.07 μM.

28458133

Caco2

Cytotoxicity assay

24 hrs

Cytotoxicity against human Caco2 cells assessed as cell viability after 24 hrs by MTT assay, IC50 = 31 μM.

28463785

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by WST8 assay, IC50 = 13.9 μM.

28488862

HT-29

Antiproliferative assay

72 hrs

Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, IC50 = 4.9 μM.

28494251

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 24.3 μM.

28494251

HepG2

Antiproliferative assay

72 hrs

Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 29.1 μM.

28494251

SW620

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 0.08 μM.

28525845

CFPAC-1

Antiproliferative assay

72 hrs

Antiproliferative activity against human CFPAC-1 cells after 72 hrs by MTT assay, IC50 = 0.14 μM.

28525845

WI38

Cytotoxicity assay

72 hrs

Cytotoxicity against human WI38 cells after 72 hrs by MTT assay, IC50 = 0.94 μM.

28525845

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 8.81 μM.

28525845

HepG2

Antiproliferative assay

72 hrs

Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 8.9 μM.

28525845

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 41.9 μM.

28532669

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay, IC50 = 4.7 μM.

28558970

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay, IC50 = 5.3 μM.

28558970

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay, IC50 = 5.6 μM.

28558970

WI38

Cytotoxicity assay

72 hrs

Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay, IC50 = 6.8 μM.

28558970

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 4 μM.

28623814

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 4.3 μM.

28623814

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 5.3 μM.

28623814

W138

Cytotoxicity assay

48 hrs

Cytotoxicity against human W138 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 5.73 μM.

28623814

P388

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse P388 cells incubated for 72 hrs by alamar blue assay, IC50 = 5.8 μM.

28648460

MOLT4

Cytotoxicity assay

72 hrs

Cytotoxicity against human MOLT4 cells incubated for 72 hrs by alamar blue assay, IC50 = 6.2 μM.

28648460

HT-29

Cytotoxicity assay

72 hrs

Cytotoxicity against human HT-29 cells incubated for 72 hrs by alamar blue assay, IC50 = 7.2 μM.

28648460

K562

Cytotoxicity assay

72 hrs

Cytotoxicity against human K562 cells incubated for 72 hrs by alamar blue assay, IC50 = 30.5 μM.

28648460

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 3.18 μM.

28666860

LNCAP

Antiproliferative assay

48 hrs

Antiproliferative activity against human LNCAP cells after 48 hrs by MTT assay, IC50 = 5.21 μM.

28666860

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells after 48 hrs by sulforhodamine B assay, GI50 = 5.47 μM.

28716495

CRL1790

Cytotoxicity assay

48 hrs

Cytotoxicity against human CRL1790 cells assessed as reduction in cell viability after 48 hrs by sulforhodamine B assay, GI50 = 10.3 μM.

28716495

SW1573

Antiproliferative assay

48 hrs

Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay, GI50 = 4.3 μM.

28728108

HBL100

Antiproliferative assay

48 hrs

Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay, GI50 = 5.5 μM.

28728108

hTERT-BJ

Antiproliferative assay

48 hrs

Antiproliferative activity against human hTERT-BJ cells after 48 hrs by SRB assay, GI50 = 5.5 μM.

28728108

HeLa

Antiproliferative assay

48 hrs

Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, GI50 = 15 μM.

28728108

T47D

Antiproliferative assay

48 hrs

Antiproliferative activity against human T47D cells after 48 hrs by SRB assay, GI50 = 47 μM.

28728108

WiDr

Antiproliferative assay

48 hrs

Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay, GI50 = 49 μM.

28728108

A549

Cytotoxicity assay

48 hrs

Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 34.47 μM.

28754470

T24

Cytotoxicity assay

48 hrs

Cytotoxicity in human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 40.14 μM.

28754470

SPCA2

Cytotoxicity assay

48 hrs

Cytotoxicity in human SPCA2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 44.34 μM.

28754470

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 28.8 μM.

28756264

SKOV3

Antiproliferative assay

48 hrs

Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay, IC50 = 32.5 μM.

28756264

NCI-H460

Antiproliferative assay

48 hrs

Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 36 μM.

28756264

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 38.5 μM.

28756264

HL-7702

Cytotoxicity assay

48 hrs

Cytotoxicity against human HL-7702 cells after 48 hrs by MTT assay, IC50 = 46 μM.

28756264

EC109

Antiproliferative assay

72 hrs

Antiproliferative activity against human EC109 cells after 72 hrs by MTT assay, IC50 = 5.01 μM.

28759876

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 6.89 μM.

28759876

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 7.21 μM.

28759876

GES-1

Cytotoxicity assay

72 hrs

Cytotoxicity against human GES-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 8.59 μM.

28759876

HGC27

Antiproliferative assay

72 hrs

Antiproliferative activity against human HGC27 cells after 72 hrs by MTT assay, IC50 = 11.02 μM.

28759876

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 5.2 μM.

28759877

PC3

Cytotoxicity assay

72 hrs

Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 13.7 μM.

28759877

SKOV3

Cytotoxicity assay

72 hrs

Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 20.8 μM.

28759877

MDA-MB-231

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 24.5 μM.

28759877

MGC803

Antiproliferative assay

48 hrs

Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 9.79 μM.

28763643

PC3

Antiproliferative assay

48 hrs

Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, IC50 = 12.87 μM.

28763643

SH-SY5Y

Antiproliferative assay

48 hrs

Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay, GI50 = 12 μM.

28763647

K562

Antiproliferative assay

48 hrs

Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, GI50 = 19 μM.

28763647

AGS

Antiproliferative assay

48 hrs

Antiproliferative activity against human AGS cells after 48 hrs by MTT assay, GI50 = 25 μM.

28763647

HeLa

Cytotoxicity assay

24 hrs

Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay, IC50 = 2.9 μM.

28838694

EC109

Antiproliferative assay

48 hrs

Antiproliferative activity against human EC109 cells after 48 hrs by MTT assay, IC50 = 6.21 μM.

28838695

MGC803

Antiproliferative assay

48 hrs

Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 7.52 μM.

28838695

MKN45

Antiproliferative assay

48 hrs

Antiproliferative activity against human MKN45 cells after 48 hrs by MTT assay, IC50 = 8.89 μM.

28838695

NCI-H1650

Antiproliferative assay

48 hrs

Antiproliferative activity against human NCI-H1650 cells after 48 hrs by MTT assay, IC50 = 14.25 μM.

28838695

EC109

Antiproliferative assay

48 hrs

Antiproliferative activity against human EC109 cells after 48 hrs by MTT assay, IC50 = 6.21 μM.

28863355

MGC803

Antiproliferative assay

48 hrs

Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 7.52 μM.

28863355

MKN45

Antiproliferative assay

48 hrs

Antiproliferative activity against human MKN45 cells after 48 hrs by MTT assay, IC50 = 8.89 μM.

28863355

GES-1

Antiproliferative assay

48 hrs

Antiproliferative activity against human GES-1 cells after 48 hrs by MTT assay, IC50 = 9.02 μM.

28863355

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 12.92 μM.

28863355

NCI-H1650

Antiproliferative assay

48 hrs

Antiproliferative activity against human NCI-H1650 cells after 48 hrs by MTT assay, IC50 = 14.25 μM.

28863355

A549

Growth inhibition assay

48 hrs

Growth inhibition of human A549 cells after 48 hrs by SRB assay, GI50 = 4.2 μM.

28898082

PC3

Growth inhibition assay

48 hrs

Growth inhibition of human PC3 cells after 48 hrs by SRB assay, GI50 = 11.7 μM.

28898082

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity in human PC3 cells incubated for 48 hrs by MTT assay, IC50 = 1.2 μM.

28923381

DU145

Cytotoxicity assay

48 hrs

Cytotoxicity in human DU145 cells incubated for 48 hrs by MTT assay, IC50 = 2.18 μM.

28923381

HCT116

Cytotoxicity assay

48 hrs

Cytotoxicity in human HCT116 cells incubated for 48 hrs by MTT assay, IC50 = 8.62 μM.

28923381

HT-29

Antitumor assay

48 hrs

Antitumor activity against human HT-29 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay, IC50 = 4.6 μM.

28926764

MCF7

Antitumor assay

48 hrs

Antitumor activity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay, IC50 = 5.7 μM.

28926764

WI38

Cytotoxicity assay

48 hrs

Cytotoxicity in human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay, IC50 = 5.7 μM.

28926764

HepG2

Antitumor assay

48 hrs

Antitumor activity against human HepG2 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay, IC50 = 6.9 μM.

28926764

L02

Antiproliferative assay

48 hrs

Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay, IC50 = 19.1 μM.

28947149

AGS

Antiproliferative assay

48 hrs

Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay, IC50 = 29.6 μM.

28947149

B16

Cytotoxicity assay

72 hrs

Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 1.19 μM.

28987604

A549

Cytotoxicity assay

72 hrs

Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 8.9 μM.

28987604

HepG2

Cytotoxicity assay

72 hrs

Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 10.4 μM.

28987604

MCF7

Cytotoxicity assay

72 hrs

Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 14.7 μM.

28987604

HL60

Antiproliferative assay

24 hrs

Antiproliferative activity against human HL60 cells treated for 24 hrs measured after 72 hrs by MTT assay, IC50 = 3.69 μM.

29037951

THP1

Antiproliferative assay

24 hrs

Antiproliferative activity against human THP1 cells treated for 24 hrs measured after 72 hrs by MTT assay, IC50 = 4.87 μM.

29037951

PC3

Antiproliferative assay

24 hrs

Antiproliferative activity against human PC3 cells treated for 24 hrs measured after 72 hrs by MTT assay, IC50 = 23.94 μM.

29037951

HepG2

Antiproliferative assay

24 hrs

Antiproliferative activity against human HepG2 cells treated for 24 hrs measured after 72 hrs by MTT assay, IC50 = 30.48 μM.

29037951

SH-SY5Y

Antiproliferative assay

48 hrs

Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay, GI50 = 11.9 μM.

29040954

K562

Antiproliferative assay

48 hrs

Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, GI50 = 18.5 μM.

29040954

AGS

Antiproliferative assay

48 hrs

Antiproliferative activity against human AGS cells after 48 hrs by MTT assay, GI50 = 24.6 μM.

29040954

EC109

Antiproliferative assay

48 hrs

Antiproliferative activity against human EC109 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 6.21 μM.

29113745

MGC803

Antiproliferative assay

48 hrs

Antiproliferative activity against human MGC803 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 7.52 μM.

29113745

MKN45

Antiproliferative assay

48 hrs

Antiproliferative activity against human MKN45 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 8.89 μM.

29113745

NCI-H1650

Antiproliferative assay

48 hrs

Antiproliferative activity against human NCI-H1650 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50 = 14.25 μM.

29113745

HL60

Antiproliferative assay

72 hrs

Antiproliferative activity against human HL60 cells after 72 hrs by tryphan blue staining based hematocytometric method, IC50 = 2.8 μM.

29131616

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 9.2 μM.

29133037

EAC

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse EAC cells assessed as reduction in cell viability after 48 hrs by trypan blue exclusion assay, IC50 = 9.6 μM.

29133037

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 10.2 μM.

29133037

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by trypan blue exclusion assay, IC50 = 10.6 μM.

29133037

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells assessed as reduction in cell viability after 48 hrs by trypan blue exclusion assay, IC50 = 10.6 μM.

29133037

DLA

Cytotoxicity assay

48 hrs

Cytotoxicity against mouse DLA cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 10.8 μM.

29133037

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by trypan blue exclusion assay, IC50 = 11.2 μM.

29133037

A549

Cytotoxicity assay

48 hrs

Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 11.4 μM.

29133037

MDA-MB-468

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs by trypan blue exclusion assay, IC50 = 44.6 μM.

29133037

MDA-MB-468

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 44.9 μM.

29133037

SW620

Antiproliferative assay

72 hrs

Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 0.08 μM.

29133046

CFPAC-1

Antiproliferative assay

72 hrs

Antiproliferative activity against human CFPAC-1 cells after 72 hrs by MTT assay, IC50 = 0.14 μM.

29133046

WI38

Antiproliferative assay

72 hrs

Antiproliferative activity against human WI38 cells after 72 hrs by MTT assay, IC50 = 0.94 μM.

29133046

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 2.8 μM.

29133046

HeLa

Antiproliferative assay

72 hrs

Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 8.81 μM.

29133046

K562

Cytotoxicity assay

48 hrs

Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 9.49 μM.

29133049

WM9

Cytotoxicity assay

48 hrs

Cytotoxicity against human WM9 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 15.8 μM.

29133049

HEL

Cytotoxicity assay

48 hrs

Cytotoxicity against human HEL cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 15.98 μM.

29133049

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 17.74 μM.

29133049

PC3

Cytotoxicity assay

48 hrs

Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 19.87 μM.

29133049

PC3

Antiproliferative assay

48 hrs

Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, IC50 = 4.75 μM.

29133051

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 8.48 μM.

29133051

SGC7901

Antiproliferative assay

48 hrs

Antiproliferative activity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 10.98 μM.

29133051

MGC803

Antiproliferative assay

48 hrs

Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 14.15 μM.

29133051

HT-29

Cytotoxicity assay

48 hrs

Cytotoxicity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 8.3 μM.

29133061

HCT15

Cytotoxicity assay

48 hrs

Cytotoxicity against human HCT15 cells after 48 hrs by MTT assay, IC50 = 7.53 μM.

29174813

Bel7402

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay, IC50 = 20.93 μM.

29174813

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 28.97 μM.

29174813

U937

Antiproliferative assay

48 hrs

Antiproliferative activity against human U937 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 9.56 μM.

29202398

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 14.52 μM.

29202398

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 15.93 μM.

29202398

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 17.02 μM.

29202398

H7402

Antiproliferative assay

48 hrs

Antiproliferative activity against human H7402 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 17.58 μM.

29202398

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 18.35 μM.

29202398

H7402

Antiproliferative assay

48 hrs

Antiproliferative activity against human H7402 cells after 48 hrs by MTT assay, IC50 = 21.87 μM.

29202398

PLC/PRF/5

Antiproliferative assay

48 hrs

Antiproliferative activity against human PLC/PRF/5 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 22.81 μM.

29202398

U937

Antiproliferative assay

48 hrs

Antiproliferative activity against human U937 cells after 48 hrs by MTT assay, IC50 = 28.76 μM.

29202398

PLC/PRF/5

Antiproliferative assay

48 hrs

Antiproliferative activity against human PLC/PRF/5 cells after 48 hrs by MTT assay, IC50 = 35.66 μM.

29202398

ES2

Antiproliferative assay

48 hrs

Antiproliferative activity against human ES2 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 37.05 μM.

29202398

U266

Antiproliferative assay

48 hrs

Antiproliferative activity against human U266 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 43.48 μM.

29202398

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells in presence of ubenimex after 48 hrs by MTT assay, IC50 = 44.06 μM.

29202398

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 2.35 μM.

29223098

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 8.638 μM.

29223717

143B

Antiproliferative assay

48 hrs

Antiproliferative activity against human 143B cells after 48 hrs by MTT assay, IC50 = 25.216 μM.

29223717

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 32.626 μM.

29223717

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 29.5 μM.

29232583

SGC7901

Antiproliferative assay

72 hrs

Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 34.4 μM.

29232583

SMMC7721

Antiproliferative assay

72 hrs

Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 37.8 μM.

29232583

HuH7

Antiproliferative assay

72 hrs

Antiproliferative activity against human HuH7 cells after 72 hrs by MTT assay, IC50 = 5.63 μM.

29316536

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 11.29 μM.

29316536

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 25.54 μM.

29316536

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 7.86 μM.

29407946

NCI-H1650

Antiproliferative assay

72 hrs

Antiproliferative activity against human NCI-H1650 cells after 72 hrs by MTT assay, IC50 = 14.63 μM.

29407946

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 27.61 μM.

29407946

HL60

Antiproliferative assay

72 hrs

Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay, IC50 = 2.37 μM.

29407983

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 18.49 μM.

29407983

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 23.86 μM.

29407983

EC9706

Antiproliferative assay

72 hrs

Antiproliferative activity against human EC9706 cells after 72 hrs by MTT assay, IC50 = 5.13 μM.

29475156

EC109

Antiproliferative assay

72 hrs

Antiproliferative activity against human EC109 cells after 72 hrs by MTT assay, IC50 = 6.02 μM.

29475156

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 6.27 μM.

29475156

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 9.24 μM.

29475156

SMMC7721

Antiproliferative assay

72 hrs

Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 13.7 μM.

29475156

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 18.75 μM.

29475156

MCF7

Antiproliferative assay

48 hrs

Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 15.78 μM.

29486954

HCT116

Antiproliferative assay

48 hrs

Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 17.25 μM.

29486954

A549

Antiproliferative assay

48 hrs

Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 19.52 μM.

29486954

HepG2

Antiproliferative assay

48 hrs

Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 23.6 μM.

29486954

QSG7701

Antiproliferative assay

24 hrs

Antiproliferative activity against human QSG7701 cells after 24 hrs by CCK-8 assay, IC50 = 6.92 μM.

29499490

SMMC7721

Antiproliferative assay

24 hrs

Antiproliferative activity against human SMMC7721 cells after 24 hrs by CCK-8 assay, IC50 = 12.47 μM.

29499490

QGY7703

Antiproliferative assay

24 hrs

Antiproliferative activity against human QGY7703 cells after 24 hrs by CCK-8 assay, IC50 = 14.2 μM.

29499490

HepG2

Antiproliferative assay

24 hrs

Antiproliferative activity against human HepG2 cells after 24 hrs by CCK-8 assay, IC50 = 15.74 μM.

29499490

HL60

Antiproliferative assay

72 hrs

Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay, IC50 = 2.37 μM.

29524728

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 18.49 μM.

29524728

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 23.86 μM.

29524728

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 8.66 μM.

29635165

PC3

Antiproliferative assay

72 hrs

Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50 = 12.33 μM.

29635165

GES-1

Antiproliferative assay

72 hrs

Antiproliferative activity against human GES-1 cells after 72 hrs by MTT assay, IC50 = 12.51 μM.

29635165

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 13.18 μM.

29635165

TE1

Antiproliferative assay

72 hrs

Antiproliferative activity against human TE1 cells after 72 hrs by MTT assay, IC50 = 16.53 μM.

29635165

HL60

Antiproliferative assay

72 hrs

Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay, IC50 = 3.46 μM.

29635169

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 18.97 μM.

29635169

SGC7901

Antiproliferative assay

72 hrs

Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 19.84 μM.

29635169

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 26.91 μM.

29635169

Caco2

Antiproliferative assay

72 hrs

Antiproliferative activity against human Caco2 cells after 72 hrs by MTT assay, IC50 = 38.77 μM.

29635169

MCF7

Cytotoxicity assay

48 hrs

Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 16.7 μM.

29657100

MDA-MB-231

Cytotoxicity assay

48 hrs

Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 35.91 μM.

29657100

DU145

Cytotoxicity assay

48 hrs

Cytotoxicity in human DU145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 39.17 μM.

29657100

A549

Cytotoxicity assay

48 hrs

Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 39.86 μM.

29657100

HepG2

Cytotoxicity assay

6 days

Cytotoxicity against human HepG2 cells after 6 days by MTT assay, IC50 = 12 μM.

29786436

SGC7901

Cytotoxicity assay

6 days

Cytotoxicity against human SGC7901 cells after 6 days by MTT assay, IC50 = 12 μM.

29786436

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 7 μM.

29908443

McCoy

Cytotoxicity assay

72 hrs

Cytotoxicity against mouse McCoy cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 15.7 μM.

29908443

PC3

Antiproliferative assay

48 hrs

Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, IC50 = 8.45 μM.

29958763

HT-29

Antiproliferative assay

48 hrs

Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 22.23 μM.

29958763

HeLa

Cytotoxicity assay

48 hrs

Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 30.21 μM.

30007564

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 36.62 μM.

30007564

IGROV1

Cytotoxicity assay

72 hrs

Cytotoxicity against human IGROV1 cells after 72 hrs, IC50 = 10.6 μM.

30035541

C13

Cytotoxicity assay

72 hrs

Cytotoxicity against human C13 cells after 72 hrs, IC50 = 12.1 μM.

30035541

HCT8

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay, IC50 = 28.9 μM.

30037494

DLD1

Antiproliferative assay

72 hrs

Antiproliferative activity against human DLD1 cells after 72 hrs by MTT assay, IC50 = 33 μM.

30037494

CCD-841-CoN

Antiproliferative assay

72 hrs

Antiproliferative activity against human CCD-841-CoN cells after 72 hrs by MTT assay, IC50 = 35.7 μM.

30037494

SKOV3

Cytotoxicity assay

48 hrs

Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay, IC50 = 26.34 μM.

30092368

HepG2

Cytotoxicity assay

48 hrs

Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 31.98 μM.

30092368

Bel7404

Cytotoxicity assay

48 hrs

Cytotoxicity against human Bel7404 cells after 48 hrs by MTT assay, IC50 = 40.21 μM.

30092368

NCI-H460

Cytotoxicity assay

48 hrs

Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay, IC50 = 45.44 μM.

30092368

RKO

Growth inhibition assay

48 hrs

Growth inhibition of human RKO cells after 48 hrs by CCK-8 assay, IC50 = 10.2 μM.

30106289

LoVo

Growth inhibition assay

48 hrs

Growth inhibition of human LoVo cells after 48 hrs by CCK-8 assay, IC50 = 11.5 μM.

30106289

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 26.14 μM.

30142612

MGC803

Antiproliferative assay

72 hrs

Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay, IC50 = 31.04 μM.

30142612

HCT116

Antiproliferative assay

72 hrs

Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 38.3 μM.

30142612

HepG2

Antiproliferative assay

72 hrs

Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 47.97 μM.

30142612

A549

Antiproliferative assay

72 hrs

Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 2.05 μM.

30243153

Bel7402

Antiproliferative assay

72 hrs

Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 18.65 μM.

30243153

MCF7

Antiproliferative assay

72 hrs

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 27.89 μM.

30243153

T84

Antiproliferative assay

3 days

Antiproliferative activity against human T84 cells after 3 days by sulforhodamine B assay, IC50 = 3.4 μM.

30248657

A549

Antiproliferative assay

3 days

Antiproliferative activity against human A549 cells after 3 days by sulforhodamine B assay, IC50 = 7.1 μM.

30248657

MCF7

Antiproliferative assay

3 days

Antiproliferative activity against human MCF7 cells after 3 days by sulforhodamine B assay, IC50 = 7.8 μM.

30248657

A549

Cytotoxicity assay

72 hrs

Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 4.3 μM.

30318440

HeLa

Cytotoxicity assay

72 hrs

Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 10.75 μM.

30318440

HCT116

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 11.56 μM.

30318440

NCI-H460

Cytotoxicity assay

72 hrs

Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay, IC50 = 11.75 μM.

30318440

HCT15

Cytotoxicity assay

72 hrs

Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50 = 11.87 μM.

30318440

MDA-MB-231

Cytotoxicity assay

72 hrs

Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 21.05 μM.

30318440

L1210/0

Function assay

Effect on L1210/0 cells in culture, IC50 = 0.3 μM.

2362278

CCRF-CEM

Function assay

Effect on CCRF-CEM cells in culture, IC50 = 2 μM.

2362278

L1210

Growth inhibition assay

Inhibition of cell growth of L1210 mouse Leukemia cells, IC50 = 0.3 μM.

2967375

L1210

Growth inhibition assay

Concentration required for the 50% inhibition of growth of L1210 mouse leukemia cells in culture, IC50 = 0.5 μM.

7120290

CCRF-CEM

Growth inhibition assay

Concentration required for the 50% inhibition of growth of CCRF-CEM human leukemia cells in culture, IC50 = 5 μM.

7120290

CHO

Growth inhibition assay

Growth inhibitory activity against CHO cells in culture., IC50 = 5 μM.

7853342

SCLC

Cytotoxicity assay

Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP), IC50 = 8.4 μM.

8258835

T-24

Cytotoxicity assay

Tested for cytotoxicity against antigen negative T-24 bladder carcinoma cells having only 3-5% antigen expression, IC50 = 4.1 μM.

8496926

791T

Cytotoxicity assay

Tested for cytotoxicity against antigen positive 791T osteosarcoma cells having only 3-5% antigen expression, IC50 = 5.5 μM.

8496926

Anticancer assay

Tested in vitro for anticancer activity against 9L cells, IC50 = 1 μM.

10072683

SK-MEL-28

Anticancer assay

Tested in vitro for anticancer activity against SK-MEL-28 cells, IC50 = 4.5 μM.

10072683

PBM

Cytotoxicity assay

Tested in vitro for cytotoxicity against PBM cells, IC50 = 5 μM.

10072683

Vero

Cytotoxicity assay

Tested in vitro for cytotoxicity against Vero cells, IC50 = 6.81 μM.

10072683

SK-MES-1

Anticancer assay

Tested in vitro for anticancer activity against SK-MES-1 cells, IC50 = 13.1 μM.

10072683

HepG2

Anticancer assay

Tested in vitro for anticancer activity against HepG2 cells, IC50 = 37.9 μM.

10072683

MCF-7

Anticancer assay

Tested in vitro for anticancer activity against MCF-7 cells, IC50 = 41 μM.

10072683

L1210

Cytotoxicity assay

In vitro cytotoxicity against murine Leukemia L1210 cells., IC50 = 0.62 μM.

10229634

Cytotoxicity assay

In vitro cytotoxicity against human oral epidermoid carcinoma KB cells., IC50 = 2.3 μM.

10229634

L1210

Growth inhibition assay

Concentration required to inhibit 50% of cell growth on murine L1210 cells., IC50 = 0.28 μM.

11052798

P388 D1

Growth inhibition assay

Concentration required to inhibit 50% of cell growth on murine P388 D1 cells., IC50 = 0.49 μM.

11052798

Molt 4/C8

Growth inhibition assay

Concentration required to inhibit 50% of cell growth on human Molt 4/C8 cells., IC50 = 23 μM.

11052798

HL60

Function assay

In vitro inhibitory concentration against proliferation of HL60 cells, IC50 = 1.5 μM.

12877593

HeLaS3

Cytotoxicity assay

Cytotoxicity against human HeLaS3 cells by WST1 assay, IC50 = 5.4 μM.

15568771

MCF-7

Antiproliferative assay

Antiproliferative activity in MCF-7 human breast cancer cells, IC50 = 4.8 μM.

15658875

MDA-MB 231

Antiproliferative assay

Antiproliferative activity in MDA-MB 231 human breast cancer cells, IC50 = 9.6 μM.

15658875

HCT116

Cytotoxicity assay

Cytotoxicity against human HCT116 cells, IC50 = 2.04 μM.

16996657

COLO205

Cytotoxicity assay

Cytotoxicity against human COLO205 cells, IC50 = 3.39 μM.

16996657

RPMI8226

Cytotoxicity assay

Cytotoxicity against human RPMI8226 cells, IC50 = 3.55 μM.

16996657

HCC2998

Cytotoxicity assay

Cytotoxicity against human HCC2998 cells, IC50 = 5.75 μM.

16996657

HCT15

Cytotoxicity assay

Cytotoxicity against human HCT15 cells, IC50 = 6.61 μM.

16996657

KM12

Cytotoxicity assay

Cytotoxicity against human KM12 cells, IC50 = 7.94 μM.

16996657

SW620

Cytotoxicity assay

Cytotoxicity against human SW620 cells, IC50 = 18.6 μM.

16996657

HT29

Antiproliferative assay

Antiproliferative activity against HT29 cells, IC50 = 7.3 μM.

17110105

Vero

Cytotoxicity assay

Cytotoxicity against Vero cells, IC50 = 0.2 μM.

17234303

SW1116

Cytotoxicity assay

Cytotoxicity against SW1116 cells by MTT colometric method, IC50 = 37 μM.

17253861

HT29

Cytotoxicity assay

Cytotoxicity against human HT29 cells by MTT microassay, IC50 = 0.6 μM.

17320246

Hep 3B

Cytotoxicity assay

Cytotoxicity against human Hep 3B cells by MTT microassay, IC50 = 0.6 μM.

17320246

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells by MTT microassay, IC50 = 1.5 μM.

17320246

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTT microassay, IC50 = 3.1 μM.

17320246

HCT116

Antitumor assay

Antitumor activity against human HCT116 cells, GI50 = 0.39811 μM.

17446077

NCI-H460

Antitumor assay

Antitumor activity against human NCI-H460 cells, GI50 = 1 μM.

17446077

SF539

Antitumor assay

Antitumor activity against human SF539 cells, GI50 = 1.25893 μM.

17446077

MCF7

Antitumor assay

Antitumor activity against human MCF7 cells, GI50 = 1.58489 μM.

17446077

HCC2998

Antitumor assay

Antitumor activity against human HCC2998 cells, GI50 = 1.58489 μM.

17446077

A549

Antitumor assay

Antitumor activity against human A549 cells, GI50 = 1.99526 μM.

17446077

CAKI-1

Antitumor assay

Antitumor activity against human CAKI-1 cells, GI50 = 3.98107 μM.

17446077

Antitumor assay

Antitumor activity against human SR cells, GI50 = 3.98107 μM.

17446077

UO31

Antitumor assay

Antitumor activity against human UO31 cells, GI50 = 5.01187 μM.

17446077

RPMI8226

Antitumor assay

Antitumor activity against human RPMI8226 cells, GI50 = 5.01187 μM.

17446077

HCT15

Antitumor assay

Antitumor activity against human HCT15 cells, GI50 = 6.30957 μM.

17446077

HT29

Antitumor assay

Antitumor activity against human HT29 cells, GI50 = 6.30957 μM.

17446077

LOX IMVI

Antitumor assay

Antitumor activity against human LOX IMVI cells, GI50 = 6.30957 μM.

17446077

COLO205

Antitumor assay

Antitumor activity against human COLO205 cells, GI50 = 6.30957 μM.

17446077

KM12

Antitumor assay

Antitumor activity against human KM12 cells, GI50 = 10 μM.

17446077

ACHN

Antitumor assay

Antitumor activity against human ACHN cells, GI50 = 10 μM.

17446077

DU145

Antitumor assay

Antitumor activity against human DU145 cells, GI50 = 10 μM.

17446077

A498

Antitumor assay

Antitumor activity against human A498 cells, GI50 = 10 μM.

17446077

MDA-MB-435

Antitumor assay

Antitumor activity against human MDA-MB-435 cells, GI50 = 10 μM.

17446077

MOLT4

Antitumor assay

Antitumor activity against human MOLT4 cells, GI50 = 12.5892 μM.

17446077

NCI-H23

Antitumor assay

Antitumor activity against human NCI-H23 cells, GI50 = 12.5892 μM.

17446077

IGROV1

Antitumor assay

Antitumor activity against human IGROV1 cells, GI50 = 12.5892 μM.

17446077

UACC62

Antitumor assay

Antitumor activity against human UACC62 cells, GI50 = 12.5892 μM.

17446077

SK-MEL-5

Antitumor assay

Antitumor activity against human SK-MEL-5 cells, GI50 = 12.5892 μM.

17446077

786-0

Antitumor assay

Antitumor activity against human 786-0 cells, GI50 = 12.5892 μM.

17446077

K562

Antitumor assay

Antitumor activity against human K562 cells, GI50 = 19.9526 μM.

17446077

HOP62

Antitumor assay

Antitumor activity against human HOP62 cells, GI50 = 19.9526 μM.

17446077

MALME-3M

Antitumor assay

Antitumor activity against human MALME-3M cells, GI50 = 19.9526 μM.

17446077

OVCAR8

Antitumor assay

Antitumor activity against human OVCAR8 cells, GI50 = 19.9526 μM.

17446077

HL60 (TB)

Antitumor assay

Antitumor activity against human HL60 (TB) cells, GI50 = 19.9526 μM.

17446077

NCI-H322

Antitumor assay

Antitumor activity against human NCI-H322 cells, GI50 = 19.9526 μM.

17446077

SN12C

Antitumor assay

Antitumor activity against human SN12C cells, GI50 = 25.1189 μM.

17446077

OVCAR-3

Antitumor assay

Antitumor activity against human OVCAR-3 cells, GI50 = 25.1189 μM.

17446077

SW620

Antitumor assay

Antitumor activity against human SW620 cells, GI50 = 25.1189 μM.

17446077

CCRF-CEM

Antitumor assay

Antitumor activity against human CCRF-CEM cells, GI50 = 31.6228 μM.

17446077

U251

Antitumor assay

Antitumor activity against human U251 cells, GI50 = 39.8107 μM.

17446077

NCI-H522

Antitumor assay

Antitumor activity against human NCI-H522 cells, GI50 = 39.8107 μM.

17446077

NCI/ADR-RES

Antitumor assay

Antitumor activity against human NCI/ADR-RES cells, GI50 = 39.8107 μM.

17446077

Caco-2

Growth inhibition assay

Growth inhibition of human Caco-2 cells, IC50 = 1.5 μM.

17548129

DLD1

Growth inhibition assay

Growth inhibition of human DLD1 cells, IC50 = 4.5 μM.

17553685

colon cancer cell

Cytotoxicity assay

Cytotoxicity against human colon cancer cells, GI50 = 5.75 μM.

17562365

L1210

Cytostatic activity assay

Cytostatic activity against mouse L1210 cells, IC50 = 0.28 μM.

17931862

CEM

Cytostatic activity assay

Cytostatic activity against human CEM cells, IC50 = 9 μM.

17931862

Molt4/C8

Cytostatic activity assay

Cytostatic activity against human Molt4/C8 cells, IC50 = 23 μM.

17931862

MCF7

Antiproliferative assay

Antiproliferative activity against human MCF7 cells, IC50 = 4.32 μM.

18194866

embryonic cell

Function assay

Induction of cleavage arrest in embryonic cells of stage 8 Xenopus laevis blastulae, IC50 = 26.8 μM.

18271558

HepG2

Cytotoxicity assay

Cytotoxicity against human HepG2 cells, IC50 = 18.7 μM.

18302336

HT29

Cytotoxicity assay

Cytotoxicity against human HT29 cells by MTT assay, IC50 = 0.6 μM.

18606546

Hep3B

Cytotoxicity assay

Cytotoxicity against human Hep3B cells by MTT assay, IC50 = 0.6 μM.

18606546

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 1.5 μM.

18606546

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTT assay, IC50 = 3.1 μM.

18606546

B16

Cytotoxicity assay

Cytotoxicity against mouse B16 cells by MTT assay, IC50 = 8.73 μM.

18644718

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTT assay, IC50 = 10.85 μM.

18644718

SW480

Cytotoxicity assay

Cytotoxicity against human SW480 cells by MTT assay, IC50 = 13.16 μM.

18644718

BEL-7402

Cytotoxicity assay

Cytotoxicity against human BEL-7402 cells by MTT assay, IC50 = 14.41 μM.

18644718

BGC-7901

Cytotoxicity assay

Cytotoxicity against human BGC-7901 cells by MTT assay, IC50 = 16.35 μM.

18644718

HL60

Cytotoxicity assay

Cytotoxicity against human HL60 cells by MTT assay, IC50 = 21.38 μM.

18644718

Cytotoxicity assay

Cytotoxicity against human KB cells by MTT assay, IC50 = 0.00446 μM.

19345581

NCI60

Growth inhibition assay

Growth inhibition of human NCI60 cells, GI50 = 17.7 μM.

19398334

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by SRB method, IC50 = 20.8 μM.

19422203

NCI-H460

Cytotoxicity assay

Cytotoxicity against human NCI-H460 cells, GI50 = 2.3 μM.

20356752

3T3

Cytotoxicity assay

Cytotoxicity against BALB mouse 3T3 cells, GI50 = 3 μM.

20356752

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells, GI50 = 4.5 μM.

20356752

DU145

Cytotoxicity assay

Cytotoxicity against human DU145 cells, GI50 = 5.3 μM.

20356752

HT-29

Cytotoxicity assay

Cytotoxicity against human HT-29 cells, GI50 = 14.9 μM.

20356752

M14

Cytotoxicity assay

Cytotoxicity against human M14 cells, GI50 = 32.4 μM.

20356752

T3M4

Cytotoxicity assay

Cytotoxicity against human T3M4 cells by crystal violet staining, IC50 = 0.33 μM.

20930123

Colo-357

Cytotoxicity assay

Cytotoxicity against human Colo-357 cells by crystal violet staining, IC50 = 2.05 μM.

20930123

Patu-T

Cytotoxicity assay

Cytotoxicity against human Patu-T cells by crystal violet staining, IC50 = 2.08 μM.

20930123

Patu-S

Cytotoxicity assay

Cytotoxicity against human Patu-S cells by crystal violet staining, IC50 = 2.93 μM.

20930123

Aspc-1

Cytotoxicity assay

Cytotoxicity against human Aspc-1 cells by crystal violet staining, IC50 = 2.97 μM.

20930123

PANC1

Cytotoxicity assay

Cytotoxicity against human PANC1 cells by crystal violet staining, IC50 = 3.94 μM.

20930123

Patu-02

Cytotoxicity assay

Cytotoxicity against human Patu-02 cells by crystal violet staining, IC50 = 3.95 μM.

20930123

DAN-G

Cytotoxicity assay

Cytotoxicity against human DAN-G cells by crystal violet staining, IC50 = 4.38 μM.

20930123

Patu-T

Cytotoxicity assay

Cytotoxicity against human 5-FU-resistant Patu-T cells by crystal violet staining, IC50 = 33.2 μM.

20930123

HeLa

Cytostatic activity assay

Cytostatic activity against human HeLa cells in presence of 20 uM 2'-deoxyuridine, IC50 = 0.18 μM.

21330014

L1210

Cytostatic activity assay

Cytostatic activity against mouse L1210 cells in presence of 500 uM uracil, IC50 = 0.47 μM.

21330014

L1210

Cytostatic activity assay

Cytostatic activity against mouse L1210 cells in presence of 500 uM uridine, IC50 = 0.62 μM.

21330014

L1210

Function assay

Inhibition of DNA synthesis in mouse L1210 cells assessed as [6-3H]2'-deoxyuridine incorporation in to DNA by liquid scintillation counting, IC50 = 0.97 μM.

21330014

HeLa

Cytostatic activity assay

Cytostatic activity against human HeLa cells in presence of 500 uM uracil, IC50 = 1 μM.

21330014

HeLa

Cytostatic activity assay

Cytostatic activity against human HeLa cells in presence of 500 uM uridine, IC50 = 1.1 μM.

21330014

L1210

Cytostatic activity assay

Cytostatic activity against mouse L1210 cells in presence of 20 uM 2'-deoxyuridine, IC50 = 1.3 μM.

21330014

HeLa

Cytostatic activity assay

Cytostatic activity against human HeLa cells in presence of 20 uM thymidine, IC50 = 1.5 μM.

21330014

L1210

Cytostatic activity assay

Cytostatic activity against mouse L1210 cells in presence of 20 uM thymidine, IC50 = 21 μM.

21330014

K562

Anticancer assay

Anticancer activity against human K562 cells, IC50 = 2.4 μM.

21449610

COLO205

Anticancer assay

Anticancer activity against human COLO205 cells, IC50 = 4.17 μM.

21449610

KM12

Anticancer assay

Anticancer activity against human KM12 cells, IC50 = 8.32 μM.

21449610

HCT116

Anticancer assay

Anticancer activity against human HCT116 cells, IC50 = 8.51 μM.

21449610

HCT15

Anticancer assay

Anticancer activity against human HCT15 cells, IC50 = 9.71 μM.

21449610

HT-29

Anticancer assay

Anticancer activity against human HT-29 cells, IC50 = 10.2 μM.

21449610

HCC2998

Anticancer assay

Anticancer activity against human HCC2998 cells, IC50 = 13.5 μM.

21449610

CCRF-CEM

Anticancer assay

Anticancer activity against human CCRF-CEM cells, IC50 = 33.1 μM.

21449610

SMMC7721

Cytotoxicity assay

Cytotoxicity against human SMMC7721 cells, IC50 = 13 μM.

21495659

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells, IC50 = 13.7 μM.

21495659

Bel7402

Cytotoxicity assay

Cytotoxicity against human Bel7402 cells, IC50 = 21.8 μM.

21495659

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTT assay, IC50 = 5.6 μM.

21515044

QGY

Cytotoxicity assay

Cytotoxicity against human QGY cells by MTT assay, IC50 = 14.1 μM.

21515044

HeLa

Cytotoxicity assay

Cytotoxicity against human HeLa cells by MTT assay, IC50 = 16.1 μM.

21515044

DU145

Cytotoxicity assay

Cytotoxicity against human DU145 cells, IC50 = 3.3 μM.

21774474

NCI-H460

Cytotoxicity assay

Cytotoxicity against human NCI-H460 cells, IC50 = 8.5 μM.

21774474

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells, IC50 = 31 μM.

21774474

L1210

Cytostatic activity assay

Cytostatic activity against mouse L1210 cells, IC50 = 0.49 μM.

21917363

HeLa

Cytostatic activity assay

Cytostatic activity against human HeLa cells, IC50 = 0.54 μM.

21917363

CEM

Cytostatic activity assay

Cytostatic activity against human CEM cells, IC50 = 18 μM.

21917363

NCI-H460

Cytotoxicity assay

Cytotoxicity against human NCI-H460 cells, IC50 = 8 μM.

22283451

SMMC7721

Cytotoxicity assay

Cytotoxicity against human SMMC7721 cells, IC50 = 15 μM.

22283451

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells, IC50 = 31 μM.

22283451

K562

Cytotoxicity assay

Cytotoxicity against human K562 cells, IC50 = 2.4 μM.

22409967

COLO205

Cytotoxicity assay

Cytotoxicity against human COLO205 cells, IC50 = 4.17 μM.

22409967

KM12

Cytotoxicity assay

Cytotoxicity against human KM12 cells, IC50 = 8.32 μM.

22409967

HCT116

Cytotoxicity assay

Cytotoxicity against human HCT116 cells, IC50 = 8.51 μM.

22409967

HCT15

Cytotoxicity assay

Cytotoxicity against human HCT15 cells, IC50 = 9.71 μM.

22409967

HT-29

Cytotoxicity assay

Cytotoxicity against human HT-29 cells, IC50 = 10.2 μM.

22409967

HCC2998

Cytotoxicity assay

Cytotoxicity against human HCC2998 cells, IC50 = 13.5 μM.

22409967

HT1080

Cytotoxicity assay

Cytotoxicity against human HT1080 cells by MTT assay, IC50 = 3.06 μM.

22801644

A375-S2

Cytotoxicity assay

Cytotoxicity against human A375-S2 cells by MTT assay, IC50 = 9.92 μM.

22801644

HeLa

Cytotoxicity assay

Cytotoxicity against human HeLa cells by MTT assay, IC50 = 10.36 μM.

22801644

HepG2

Cytotoxicity assay

Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 10.45 μM.

22801644

BGC823

Cytotoxicity assay

Cytotoxicity against human BGC823 cells by MTT assay, IC50 = 15.65 μM.

22801644

Hep2

Cytotoxicity assay

Cytotoxicity against human Hep2 cells by MTT assay, IC50 = 24.58 μM.

22801644

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 24.58 μM.

22801644

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTT assay, IC50 = 31.52 μM.

22801644

MDA231

Cytotoxicity assay

Cytotoxicity against human MDA231 cells by MTT assay, IC50 = 31.57 μM.

22801644

PC3

Cytotoxicity assay

Cytotoxicity against human PC3 cells by MTT assay, IC50 = 35.75 μM.

22801644

2008

Growth inhibition assay

Growth inhibition of human 2008 cells by crystal violet assay, IC50 = 4.2 μM.

23075414

Vero

Growth inhibition assay

Growth inhibition of african green monkey Vero cells by crystal violet assay, IC50 = 4.5 μM.

23075414

A2780

Growth inhibition assay

Growth inhibition of human A2780 cells by crystal violet assay, IC50 = 5.1 μM.

23075414

C13

Growth inhibition assay

Growth inhibition of cDDP-resistant human C13 cells by crystal violet assay, IC50 = 8.5 μM.

23075414

A2780/CP70

Growth inhibition assay

Growth inhibition of cDDP-resistant human A2780/CP70 cells by crystal violet assay, IC50 = 12.3 μM.

23075414

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTT method, IC50 = 1.54 μM.

23164710

BGC823

Cytotoxicity assay

Cytotoxicity against human BGC823 cells by MTT method, IC50 = 3.84 μM.

23164710

Bel7042

Cytotoxicity assay

Cytotoxicity against human Bel7042 cells by MTT method, IC50 = 3.85 μM.

23164710

HCT8

Cytotoxicity assay

Cytotoxicity against human HCT8 cells by MTT method, IC50 = 5.38 μM.

23164710

A2780

Cytotoxicity assay

Cytotoxicity against human A2780 cells by MTT method, IC50 = 5.4 μM.

23164710

NIH-H460

Cytotoxicity assay

Cytotoxicity against human NIH-H460 cells by MTT method, IC50 = 7.12 μM.

23164710

HCT8

Antiproliferative assay

Antiproliferative activity against human HCT8 cells by MTT assay, IC50 = 6.92 μM.

24095094

Bel7402

Antiproliferative assay

Antiproliferative activity against human Bel7402 cells by MTT assay, IC50 = 8.3 μM.

24095094

A549

Antiproliferative assay

Antiproliferative activity against human A549 cells by MTT assay, IC50 = 8.92 μM.

24095094

DU145

Cytotoxicity assay

Cytotoxic activity against human DU145 cells, IC50 = 3.4 μM.

24195466

NCI-H460

Cytotoxicity assay

Cytotoxic activity against human NCI-H460 cells, IC50 = 8.5 μM.

24195466

SMMC7721

Antiproliferative assay

Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell proliferation by CCK8 assay, IC50 = 5.62 μM.

25442303

A549

Antiproliferative assay

Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by CCK8 assay, IC50 = 8.13 μM.

25442303

MCF7

Antiproliferative assay

Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation by CCK8 assay, IC50 = 14.26 μM.

25442303

L1210

Cytotoxicity assay

Cytotoxicity against mouse L1210 cells assessed as inhibition of cell proliferation, IC50 = 0.33 μM.

26001344

HeLa

Cytotoxicity assay

Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation, IC50 = 0.54 μM.

26001344

CEM

Cytotoxicity assay

Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation, IC50 = 18 μM.

26001344

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.1 μM.

26629861

Neuro2a

Cytotoxicity assay

Cytotoxicity against mouse Neuro2a cells assessed as cell growth inhibition by MTT assay, IC50 = 1.2 μM.

26629861

HeLa

Cytotoxicity assay

Cytotoxicity against human HeLa cells assessed as cell growth inhibition by MTT assay, IC50 = 1.5 μM.

26629861

COLO205

Cytotoxicity assay

Cytotoxicity against human COLO205 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.8 μM.

26629861

HepG2

Cytotoxicity assay

Cytotoxicity against human HepG2 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.3 μM.

27561719

DU145

Cytotoxicity assay

Cytotoxicity against human DU145 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.6 μM.

27561719

MDA-MB-231

Cytotoxicity assay

Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.8 μM.

27561719

HeLa

Cytotoxicity assay

Cytotoxicity against human HeLa cells assessed as cell growth inhibition by MTT assay, IC50 = 1.9 μM.

27561719

HeLa

Cytotoxicity assay

Cytotoxicity against human HeLa cells assessed as cell growth inhibition by MTT assay, IC50 = 1.6 μM.

27720296

PC3

Cytotoxicity assay

Cytotoxicity against human PC3 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.8 μM.

27720296

HepG2

Cytotoxicity assay

Cytotoxicity against human HepG2 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.8 μM.

27720296

MDA-MB-231

Cytotoxicity assay

Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay, IC50 = 1.9 μM.

27720296

PC9

Cytotoxicity assay

Cytotoxicity against human PC9 cells assessed as growth inhibition by MTT assay, IC50 = 1.99 μM.

27769034

MGC803

Cytotoxicity assay

Cytotoxicity against human MGC803 cells assessed as growth inhibition by MTT assay, IC50 = 10.14 μM.

27769034

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells assessed as growth inhibition by MTT assay, IC50 = 13.95 μM.

27769034

EC109

Cytotoxicity assay

Cytotoxicity against human EC109 cells assessed as growth inhibition by MTT assay, IC50 = 25.99 μM.

27769034

Hep3B

Cytotoxicity assay

Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assay, IC50 = 9.36 μM.

27913179

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay, IC50 = 16.63 μM.

27913179

HepG2

Cytotoxicity assay

Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 2.1 μM.

28262527

Hep3B

Cytotoxicity assay

Cytotoxicity against human Hep3B cells by MTT assay, IC50 = 2.66 μM.

28262527

HCT116

Cytotoxicity assay

Cytotoxicity in human HCT116 cells assessed as reduction in cell viability by MTT assay, IC50 = 41 μM.

28334654

MCF7

Cytotoxicity assay

Cytotoxicity in human MCF7 cells assessed as reduction in cell viability by MTT assay, IC50 = 41.5 μM.

28334654

Hep3B

Cytotoxicity assay

Cytotoxicity against human Hep3B cells by MTT assay, IC50 = 11.9 μM.

28371676

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 30 μM.

28371676

HepG2

Cytotoxicity assay

Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 32.6 μM.

28371676

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTT assay, IC50 = 38.2 μM.

28371676

MCF7

Cytotoxicity assay

Cytotoxicity against human MCF7 cells, IC50 = 7.9 μM.

28431341

HepG2

Cytotoxicity assay

Cytotoxicity against human HepG2 cells, IC50 = 8.1 μM.

28431341

HCT116

Cytotoxicity assay

Cytotoxicity against human HCT116 cells, IC50 = 9.9 μM.

28431341

PC3

Cytotoxicity assay

Cytotoxic activity against human PC3 cells, IC50 = 1.6 μM.

28697923

HL60

Cytotoxicity assay

Cytotoxic activity against human HL60 cells, IC50 = 2.8 μM.

28697923

HCT116

Cytotoxicity assay

Cytotoxic activity against human HCT116 cells, IC50 = 17.01 μM.

28697923

PC3

Antiproliferative assay

Antiproliferative activity against human PC3 cells by MTT assay, IC50 = 22.02 μM.

29131616

HeLa

Cytotoxicity assay

Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay, IC50 = 28 μM.

29489361

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells assessed as decrease in cell viability by MTT assay, IC50 = 36.8 μM.

29489361

HepG2

Antiproliferative assay

Antiproliferative activity against human HepG2 cells by MTT assay, IC50 = 1.7 μM.

29798826

HeLa

Antiproliferative assay

Antiproliferative activity against human HeLa cells by MTT assay, IC50 = 1.8 μM.

29798826

MCF7

Antiproliferative assay

Antiproliferative activity against human MCF7 cells by MTT assay, IC50 = 1.8 μM.

29798826

COLO205

Antiproliferative assay

Antiproliferative activity against human COLO205 cells by MTT assay, IC50 = 1.9 μM.

29798826

HEK293

Antiproliferative assay

Antiproliferative activity against human HEK293 cells by MTT assay, IC50 = 19.6 μM.

29798826

A549

Cytotoxicity assay

Cytotoxicity against human A549 cells by MTS assay, IC50 = 3.52 μM.

29843103

HCT116

Cytotoxicity assay

Cytotoxicity against human HCT116 cells by MTS assay, IC50 = 5.53 μM.

29843103

2008

Cytotoxicity assay

Cytotoxicity against human 2008 cells, IC50 = 6 μM.

30035541

点击查看更多细胞系数据

生物活性

产品描述

5-FU (5-Fluorouracil)是DNA/RNA合成抑制剂，在肿瘤细胞中通过抑制胸苷酸合成酶（TS）而干扰核苷酸合成。Fluorouracil 可诱导细胞凋亡并可用于治疗HIV。

靶点

Thymidylate synthase [1](Tumor cells)

体外研究(In Vitro)

体外研究活性

Adrucil是一种尿嘧啶类似物，在C-5位置上有一个氟原子。利用和尿嘧啶一致的转运途径快速进入细胞。Adrucil在细胞内转化成几个活性代谢物：氟脱氧尿苷单磷酸盐(FdUMP)，氟脱氧尿苷三磷酸盐(FdUTP) 以及氟尿苷三磷酸盐 (FUTP)。Adrucil的代谢物FdUMP结合到TS核苷酸结合位点，与CH2THF形成稳定的三聚体，进而阻断了正常的底物dUMP的结合，抑制了dTMP的合成。Adrucil代谢物能够插入DNA，导致DNA双链断裂和细胞死亡。Adrucil的促凋亡作用可能和激活肿瘤抑制因子P53有关。P53功能缺失降低细胞对Adrucil的敏感性。[1]Adrucil抑制存活诱导各种细胞的凋亡。Adrucil 抑制鼻咽癌细胞系CNE2 和 HONE的生存能力[2]，Adrucil抑制Capan-1细胞的生存能力[3]，Adrucil抑制HT-29细胞的生存能力[4]，IC50 分别是 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM。

细胞实验

细胞系

人类结肠癌细胞系 HT-29

浓度

~25 μM

孵育时间

7天

方法

在96孔板中Adrucil处理细胞7天后测量生长抑制(4000 HT-29 细胞/孔，在含10%透析的牛胎儿血清RPMI 1640 培养基中)；细胞附着过夜后加入增加浓度的Adrucil。在培养结束时，细胞用磷酸盐缓冲盐水(pH 7.4)清洗3次，用10%三氯乙酸在4 ℃下固定 60分钟。用去离子水洗5次，加入0.4% 磺酰罗丹明溶液在室温染色15分钟。未被磺酰罗丹明着色的通过1%冰乙酸漂洗去除。然后，着色的细胞蛋白质干燥，溶解于10 mM Tris-HCl。探测器在540nm波长处测定光密度值。

实验图片

检测方法

检测指标

实验图片

PMID

Western blot

p53 / PUMA / c-PARP

25965911

Immunofluorescence

caveolin-3

phospho-histone H3

p65 / p-p65(Ser536) / p53 / p-p53(Ser15)

Sox2 / Oct4 / Nanog / ABCG2

β-catenin

non-phospho β-catenin

23646193

Growth inhibition assay

Cell viability

Cell proliferation

25965911

体内研究(In Vivo)

体内研究活性

Adrucil在治疗包括结肠癌，乳腺癌等各种癌症中有广泛应用。 [1]100毫克/千克 Adrucil显著抑制患有结肠癌小鼠的结肠Colon 38的生长，肿瘤复制时间(TD)，生长延缓因子(GDF)，和T/C分别是26.5 days，4.4, 和14%。[5]

动物实验

Animal Models

38小鼠结肠癌结肠38

Dosages

100毫克/千克

Administration

每周一次腹腔注射

临床试验信息

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number

Recruitment

Conditions

Sponsor/Collaborators

Start Date

Phases

NCT06361316

Recruiting

Pancreatic Cancer|Adjuvant Therapy

Kuirong Jiang|CSPC Ouyi Pharmaceutical Co. Ltd.|The First Affiliated Hospital with Nanjing Medical University

April 8 2024

Not Applicable

NCT05780684

Recruiting

Colorectal Cancer|Esophagus Cancer|Appendix Cancer|Small Bowel Cancer|Ampullary Cancer

Dartmouth-Hitchcock Medical Center

July 14 2023

Not Applicable

NCT05362955

Active not recruiting

CIN 2/3|HIV Infections

UNC Lineberger Comprehensive Cancer Center

April 26 2023

Phase 1

NCT05620524

Recruiting

TDM of 5-FU|Pharmacokinetic Observational Study

Catharina Ziekenhuis Eindhoven

December 19 2022

NCT05505539

Withdrawn

Oral Leukoplakia

University of California San Francisco

September 30 2022

Phase 1

参考文献

[1]https://pubmed.ncbi.nlm.nih.gov/12724731/

[2]https://pubmed.ncbi.nlm.nih.gov/18452707/

[3]https://pubmed.ncbi.nlm.nih.gov/12138244/

[4]https://pubmed.ncbi.nlm.nih.gov/7642571/

[5]https://pubmed.ncbi.nlm.nih.gov/8995503/

+ 展开

化学信息&溶解度

分子量

130.08

分子式

C4H3FN2O2

CAS号

51-21-8

SDF

Download 5-Fluorouracil (5-FU) SDF

Smiles

C1=C(C(=O)NC(=O)N1)F

储存条件(自收到货起)

3年-20°C粉状

储备液保存和期限建议分装储备液，避免反复冻融！

1年-80°C溶于溶剂

1个月-20°C溶于溶剂

体外溶解度批次：

S120901

S120904

S120905

S120906

DMSO

: 26 mg/mL

(

(199.87 mM)

；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO)

Water

: Insoluble

Ethanol

: Insoluble

DMSO

: 26 mg/mL

(

(199.87 mM)

；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO)

Water

: 10 mg/mL

(76.87 mM)

Ethanol

: Insoluble

DMSO

: 26 mg/mL

(

(199.87 mM)

；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO)

Water

: 10 mg/mL

(76.87 mM)

Warmed with 50°C water bath;

Ultrasonicated;

Ethanol

: Insoluble

DMSO

: 100 mg/mL

(

(768.75 mM)

；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO)

Water

: 8 mg/mL

(61.5 mM)

Ethanol

: Insoluble

摩尔浓度计算器

体内溶解配方批次：

S120901

S120904

S120905

S120906

现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂

动物体内配方计算器

均匀悬浊液

CMC-NA

≥5mg/ml

以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。

均匀悬浊液

CMC-NA

≥5mg/ml

以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。

均匀悬浊液

CMC-NA

≥5mg/ml

以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。

均匀悬浊液

CMC-NA

≥5mg/ml

以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。

澄清溶液

5%DMSO

Corn oil

该配方已经过Selleck实验室实测。如果上述溶解方案不能满足您的需求，可联系Selleck销售提供定制化测试。

0.650mg/ml

(5.00mM)

以 1 mL 工作液为例，取50μL13mg/ml的澄清DMSO储备液加到950μL玉米油中，混合均匀。工作液请现配现用！

澄清溶液

5%DMSO

40%PEG300

5%Tween80

50%ddH2O

该配方已经过Selleck实验室实测。如果上述溶解方案不能满足您的需求，可联系Selleck销售提供定制化测试。

3.500mg/ml

(26.91mM)

以 1 mL 工作液为例,取50μL70mg/ml的澄清DMSO储备液加到400μLPEG300中,混合均匀使其澄清;向上述体系中加入50μLTween80,混合均匀使其澄清;然后继续加入500μLddH2O定容至1mL。工作液请现配现用!

实验计算

摩尔浓度计算器

质量

浓度

体积

分子量

μg

μM

μL

计算

重置

稀释计算器

分子量计算器

动物体内配方计算器（澄清溶液）

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积 μL

动物数量只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO +

PEG300

Corn oil

% Tween 80

% ddH2O

%DMSO+

Corn oil

PEG300

计算重置

计算结果：

工作液浓度： mg/ml；

DMSO母液配制方法： mg

药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取μL

DMSO母液，加入μL PEG300，混匀澄清后加入μL

Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。

体内配方配制方法：取μL

DMSO母液，加入μL Corn oil，混匀澄清。

注意：1. 首先保证母液是澄清的；

2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

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常见问题及建议解决方法

问题 1:

I was wondering if it is suitable to inject this compound into mice ?

回答：

It is suitable to inject (I.P.) into mice as indicated in this paper: http://www.ncbi.nlm.nih.gov/pubmed/8995503.

5-Fluorouracil (5-FU)

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